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PLCH1 Knockout Cell Lines

Gene: PLCH1

Official Full Name: phospholipase C eta 1provided by HGNC

Gene Summary: PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30034 PLCH1 Knockout cell line (HCT 116) Human PLCH1 1:2~1:4 Negative Online Inquiry
KO30035 PLCH1 Knockout cell line (HEK293) Human PLCH1 1:3~1:6 Negative Online Inquiry
KO30036 PLCH1 Knockout cell line (A549) Human PLCH1 1:3~1:4 Negative Online Inquiry

Background

PLCH1 Gene Knockout Cell Lines are specialized cellular models engineered to disable the phospholipase C homolog 1 (PLCH1) gene, which plays a crucial role in various signaling pathways implicated in cell growth, differentiation, and apoptosis. These knockout cell lines are generated through state-of-the-art genome-editing technologies, providing researchers with a powerful tool to study the functional impact of PLCH1 deficiency in both in vitro and in vivo systems.

The primary function of PLCH1 is to hydrolyze phosphatidylinositol 4,5-bisphosphate, leading to the activation of downstream signaling cascades that regulate critical cellular processes. By knocking out this gene, researchers can elucidate the biological roles of PLCH1 and its influence on cellular behaviors in disease contexts, such as cancer or neurodegenerative disorders. This knockdown facilitates targeted investigations into the molecular mechanisms that underpin PLCH1’s involvement in pathological states.

The scientific significance of these knockout cell lines extends to their applications in drug discovery, genetic research, and therapeutic development. They provide a valuable model for understanding the phenotypic consequences of PLCH1 loss, aiding in the identification of potential drug targets and the validation of therapeutic strategies. Moreover, by utilizing these knockout cell lines, researchers can better assess the effectiveness of novel compounds and their mechanism of action.

What sets our PLCH1 Gene Knockout Cell Lines apart from alternative products on the market is our commitment to rigorous validation processes, ensuring that the cell lines demonstrate consistent and reproducible loss of PLCH1 function. Furthermore, we provide comprehensive support in the form of detailed product documentation and consultation services, allowing researchers to maximize the utility of these models in their specific applications.

In a landscape where precise modeling of human diseases is paramount, the PLCH1 Gene Knockout Cell Lines represent a unique opportunity for researchers and clinicians aiming to deepen their understanding of signaling pathways and disease mechanisms. Backed by our company’s extensive expertise in cell line development and molecular biology, we are dedicated to equipping the scientific community with high-quality, dependable tools for groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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