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PLB1 Knockout Cell Lines

Gene: PLB1

Official Full Name: phospholipase B1provided by HGNC

Gene Summary: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22010 PLB1 Knockout cell line (A549) Human PLB1 1:3~1:4 Negative Online Inquiry

Background

PLB1 Gene Knockout Cell Lines are genetically engineered models crucial for the in-depth study of the PLB1 gene, which encodes the phospholipase B1 enzyme involved in lipid metabolism. These cell lines are specifically designed to exhibit a complete knockout of the PLB1 gene, enabling researchers to elucidate the physiological functions of this enzyme and understand its role in various biological processes and diseases.

The key mechanism of action for PLB1 Gene Knockout Cell Lines involves the use of advanced CRISPR/Cas9 technology that precisely targets and disrupts the PLB1 gene. This alteration allows researchers to investigate the consequences of gene loss, including the investigation of metabolic dysregulation, signaling pathways, and potential effects on cell viability and proliferation. Thus, these cell lines serve as invaluable tools for dissecting the complex roles of lipid metabolism in health and disease.

In terms of scientific importance, PLB1 Gene Knockout Cell Lines are utilized in a variety of research applications, from basic cellular biology and biochemistry to translational research and drug development. They are particularly relevant in studying metabolic disorders, cancer biology, and neurodegenerative diseases, where lipid metabolism has been implicated in disease progression.

Compared to alternative models, including wild-type cell lines or other knockout systems, PLB1 Gene Knockout Cell Lines offer unique advantages such as high specificity, reproducibility, and the ability to generate consistent experimental results. This specificity minimizes off-target effects, which are critical for obtaining reliable data and ensuring the integrity of scientific findings.

Researchers and clinicians will find PLB1 Gene Knockout Cell Lines exceptionally valuable as they provide a controlled environment to validate hypotheses and screen for therapeutic interventions. The ability to operate with precision in studying gene function makes these cell lines an indispensable asset in the quest to develop novel strategies for disease management.

Our company has extensive expertise in genetic engineering and cell line development, ensuring that PLB1 Gene Knockout Cell Lines are of the highest quality and reliability, thus supporting the advancement of integrated biological research and therapeutic applications.

Please note that all services are for research use only. Not intended for any clinical use.

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