Gene: PLA2R1
Official Full Name: phospholipase A2 receptor 1provided by HGNC
Gene Summary: This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30117 | PLA2R1 Knockout cell line (HeLa) | Human | PLA2R1 | 1:3~1:6 | Negative | Online Inquiry |
KO30118 | PLA2R1 Knockout cell line (A549) | Human | PLA2R1 | 1:3~1:4 | Negative | Online Inquiry |
PLA2R1 Gene Knockout Cell Lines are genetically modified cell lines that specifically lack the expression of the Phospholipase A2 Receptor 1 (PLA2R1) gene. This innovative product allows researchers to study the functional consequences of PLA2R1 loss in various biological contexts, particularly in investigations related to autoimmune diseases, kidney disorders, and cancer progression. The precise mechanism of action involves the targeted deletion of the PLA2R1 gene using CRISPR/Cas9 technology, ensuring a high degree of specificity while minimizing off-target effects.
The scientific importance of these knockout cell lines lies in their utility for dissecting the role of PLA2R1 in pathophysiological conditions. They provide a powerful tool for understanding the receptor's involvement in modulating immune responses and inflammation. In clinical settings, these cell lines can facilitate drug discovery and biomarker identification, enabling researchers to explore potential therapeutic targets for conditions associated with altered PLA2R1 activity.
Compared to alternative models, such as wild-type cell lines or less specific knockdown systems, the PLA2R1 Gene Knockout Cell Lines offer unmatched precision. They allow for robust and reproducible results without the variability associated with transient gene knockdown approaches. Additionally, these knockout lines can be used in high-throughput screening assays, expediting the research process.
For researchers and clinicians focused on the intricate interplay between immune regulation and disease, the value of PLA2R1 Gene Knockout Cell Lines is substantial. They empower scientists to generate insights that could lead to groundbreaking therapies and interventions.
At [Your Company Name], we pride ourselves on our commitment to advancing scientific research through high-quality biological products. Our expertise in gene editing technologies ensures that our offerings meet the highest standards of precision and reliability, enabling you to achieve your research goals with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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