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PJVK Knockout Cell Lines

Gene: PJVK

Official Full Name: pejvakinprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06677 PJVK Knockout cell line (HeLa) Human PJVK 1:3~1:6 Negative Online Inquiry
KO06678 PJVK Knockout cell line (HCT 116) Human PJVK 1:2~1:4 Negative Online Inquiry
KO06679 PJVK Knockout cell line (A549) Human PJVK 1:3~1:4 Negative Online Inquiry

Background

PJVK Gene Knockout Cell Lines are genetically engineered cell lines where the PJVK gene, crucial for the development of specific biological functions, has been effectively disrupted. This targeted alteration is achieved using CRISPR/Cas9 technology, enabling precise gene editing that allows researchers to study the role of the PJVK gene in various biological processes, including auditory function and cellular responses to environmental stimuli.

The primary function of these knockout cell lines lies in elucidating the physiological and pathological roles of the PJVK gene. By comparing the knockout lines to wild-type controls, researchers can investigate alterations in cellular behavior, gene expression profiles, and molecular pathways influenced by PJVK. This mechanistic understanding is invaluable in diverse fields such as audiology, neurology, and developmental biology, where the consequences of gene mutations can shed light on disease mechanisms and potential therapeutic interventions.

The scientific importance of PJVK Gene Knockout Cell Lines extends into both research and clinical applications. They serve as a powerful tool for drug discovery and development, enabling screening for compounds that could modify the effects of PJVK gene disruption. Additionally, these models can facilitate the study of gene-environment interactions, paving the way for advancements in personalized medicine.

Compared to alternative models, such as transient knockdown systems or non-targeted genetic modifications, the PJVK Gene Knockout Cell Lines provide greater specificity and stability for long-term studies. Their ability to maintain consistent genetic backgrounds allows for reproducible results and comparability across experiments, significantly enhancing the reliability of data obtained from such studies.

For researchers and clinicians, the value of PJVK Gene Knockout Cell Lines is evident in their capability to bridge the gap between genotype and phenotype in complex biological systems. They empower users to uncover insights that could lead to groundbreaking therapeutic strategies and a deeper understanding of gene function in health and disease.

Our company, with rich expertise in genetic engineering and a commitment to providing high-quality biological products, offers these knockout cell lines to facilitate cutting-edge research. We strive to support the scientific community in their quest for knowledge and innovation, ensuring reliability and excellence in every product we deliver.

Please note that all services are for research use only. Not intended for any clinical use.

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