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PIDD1 Knockout Cell Lines

Gene: PIDD1

Official Full Name: p53-induced death domain protein 1provided by HGNC

Gene Summary: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15151 PIDD1 Knockout cell line (HeLa) Human PIDD1 1:3~1:6 Negative Online Inquiry
KO15152 PIDD1 Knockout cell line (HCT 116) Human PIDD1 1:2~1:4 Negative Online Inquiry
KO15153 PIDD1 Knockout cell line (HEK293) Human PIDD1 1:3~1:6 Negative Online Inquiry
KO15154 PIDD1 Knockout cell line (A549) Human PIDD1 1:3~1:4 Negative Online Inquiry

Background

PIDD1 Gene Knockout Cell Lines are specifically engineered cellular models in which the PIDD1 (p53-induced death domain protein 1) gene has been disrupted, allowing researchers to study the gene's functions in a controlled environment. PIDD1 plays a critical role in apoptosis and NF-κB signaling pathways, making these knockout cell lines essential for investigating various cellular processes related to cell survival, inflammation, and DNA damage response.

These cell lines function by lacking the expression of PIDD1, enabling scientists to observe phenotypic changes and molecular mechanisms that arise from the absence of this protein. Researchers can utilize these models to explore the implications of PIDD1 loss in cancer pathogenesis, neurodegenerative diseases, and immune responses, thus unraveling potential therapeutic targets. The manipulation of these pathways in PIDD1 knockout cells provides insights into cellular stress responses and the intricate balance between cell survival and death.

The scientific significance of PIDD1 Gene Knockout Cell Lines extends into both research and clinical arenas, as they serve as invaluable tools for elucidating disease mechanisms and potential drug interactions. Compared to traditional models, these knockout cell lines offer specificity and reproducibility, which are crucial for generating consistent and meaningful data. The targeted disruption allows for a clearer understanding of gene function without the complication of functional redundancies often encountered in wild-type cells.

For researchers and clinicians looking to gain a deeper understanding of PIDD1-related pathways and their implications in health and disease, these knockout cell lines offer unparalleled advantages, including robust experimental versatility and substantial capability for downstream analyses such as gene expression studies, drug response assays, or metabolic profiling.

Our company is committed to advancing scientific research by providing high-quality, reliable biological products. With our expertise in genetic engineering and a dedication to innovation, we ensure that our PIDD1 Gene Knockout Cell Lines empower researchers and clinicians to push the boundaries of discovery in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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