Gene: PHRF1
Official Full Name: PHD and ring finger domains 1provided by HGNC
Gene Summary: Predicted to enable RNA polymerase binding activity. Predicted to be involved in protein ubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15167 | PHRF1 Knockout cell line (HeLa) | Human | PHRF1 | 1:3~1:6 | Negative | Online Inquiry |
KO15168 | PHRF1 Knockout cell line (HCT 116) | Human | PHRF1 | 1:2~1:4 | Negative | Online Inquiry |
KO15169 | PHRF1 Knockout cell line (HEK293) | Human | PHRF1 | 1:3~1:6 | Negative | Online Inquiry |
KO15170 | PHRF1 Knockout cell line (A549) | Human | PHRF1 | 1:3~1:4 | Negative | Online Inquiry |
PHRF1 Gene Knockout Cell Lines are genetically engineered cell lines in which the PHRF1 gene has been inactivated, allowing researchers to investigate the specific functions and downstream effects of this gene in various biological contexts. The PHRF1 gene, which is implicated in critical processes such as cell cycle regulation, DNA damage response, and tumor biology, serves as a promising target for understanding the molecular underpinnings of cancer and other diseases.
The key mechanism of these knockout cell lines revolves around CRISPR-Cas9 technology, which enables precise editing of the genome by creating double-stranded breaks at targeted locations. This allows for the efficient disruption of the PHRF1 gene, leading to a lack of functional protein production. Researchers can utilize these cell lines to study altered phenotypic traits, including cellular proliferation, apoptosis, and signaling pathways, elucidating the gene's role in various physiological and pathological processes.
In research settings, the availability of PHRF1 Gene Knockout Cell Lines is invaluable for both basic and applied studies. They facilitate the exploration of cancer biology, drug resistance mechanisms, and potential therapeutic targets. Clinically, such models can advance the development of targeted therapies and improve our understanding of patient-specific gene expression profiles.
Compared to traditional knockout models, which can be time-consuming and inefficient, our PHRF1 Gene Knockout Cell Lines are ready to use and validated for reproducibility and consistency. This ensures that researchers spend less time on preliminary studies and more time on significant discoveries.
The value of these cell lines extends beyond mere genetic manipulation; they offer a powerful tool to unravel complex biological networks critical for disease progression. Our commitment to providing high-quality biological products is backed by years of expertise and innovation in genetic engineering, ensuring that our customers have access to the best resources for their research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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