Gene: PHOSPHO1
Official Full Name: phosphoethanolamine/phosphocholine phosphatase 1provided by HGNC
Gene Summary: Enables phosphocholine phosphatase activity; phosphoethanolamine phosphatase activity; and pyrophosphatase activity. Predicted to be involved in bone mineralization involved in bone maturation. Predicted to act upstream of or within endochondral ossification. Predicted to be located in cytosol. Predicted to be active in extracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30501 | PHOSPHO1 Knockout cell line (HCT 116) | Human | PHOSPHO1 | 1:2~1:4 | Negative | Online Inquiry |
PHOSPHO1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically developed to lack the expression of the PHOSPHO1 gene, which encodes for an enzyme critical in phospholipid metabolism and bone mineralization. This innovative product enables researchers to study the functional role of PHOSPHO1 in cellular processes, including cell signaling, lipid metabolism, and mineral deposition, providing a platform to explore its implications in both normal physiological and pathological states.
These cell lines operate on a mechanism of gene disruption achieved through advanced CRISPR-Cas9 technology, allowing for precise editing of the genome to create knockout models that can be used for various experimental designs. By systematically eliminating the PHOSPHO1 gene, users can observe the resultant phenotypic changes and assess the biochemical pathways that are affected, thereby advancing our understanding of osteogenic differentiation and mineralization-related disorders.
The scientific importance of PHOSPHO1 Gene Knockout Cell Lines is evident in both research and clinical applications. These models facilitate studies on osteoporosis, rickets, and other skeletal abnormalities linked to dysfunctional mineralization. They are critical tools for drug development and validation and can support gene therapy approaches aiming to address genetic deficiencies.
When compared to traditional cell lines or other knockout models, our PHOSPHO1 Gene Knockout Cell Lines offer unique advantages, including high specificity, reproducibility, and the ability to maintain the native cellular environment. Furthermore, the ease of use in standard laboratory protocols any researchers, ensuring a seamless integration into ongoing projects.
This product is invaluable to researchers and clinicians looking to uncover the complexities of bone biology and mineralization disorders. By leveraging these knockout cell lines, scientists can develop targeted interventions and therapeutics with the potential to significantly impact patient outcomes.
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Please note that all services are for research use only. Not intended for any clinical use.
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