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PHLDA3 Knockout Cell Lines

Gene: PHLDA3

Official Full Name: pleckstrin homology like domain family A member 3provided by HGNC

Gene Summary: Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04737 PHLDA3 Knockout cell line (HeLa) Human PHLDA3 1:3~1:6 Negative Online Inquiry
KO04738 PHLDA3 Knockout cell line (HCT 116) Human PHLDA3 1:2~1:4 Negative Online Inquiry
KO04739 PHLDA3 Knockout cell line (HEK293) Human PHLDA3 1:3~1:6 Negative Online Inquiry
KO04740 PHLDA3 Knockout cell line (A549) Human PHLDA3 1:3~1:4 Negative Online Inquiry

Background

PHLDA3 Gene Knockout Cell Lines are engineered cellular models specifically designed to facilitate the study of the PHLDA3 gene, which plays a crucial role in various biological processes including cell cycle regulation and apoptosis. By employing the CRISPR/Cas9 genome editing technology, these cell lines have undergone targeted disruption of the PHLDA3 gene, allowing researchers to analyze the functional consequences of its absence in a controlled environment.

The mechanisms by which PHLDA3 influences cellular behaviors are critical for understanding its implications in developmental biology and cancer research. The knockout of this gene can reveal the molecular pathways affected, providing insights into regulatory networks that govern cell survival and proliferation. This is particularly valuable in research settings that aim to unravel the complexities of tumorigenesis, as PHLDA3 has been implicated as a tumor suppressor in various malignancies.

What sets our PHLDA3 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility. Utilizing advanced gene-editing techniques ensures a complete knockout, which is essential for obtaining consistent and reliable experimental results. Additionally, these cell lines are validated for their performance in a variety of assays, including proliferation, migration, and invasion studies, making them versatile tools for researchers in oncology.

For researchers and clinicians, these knockout cell lines offer a unique opportunity to accelerate discovery in gene function and therapeutic development, particularly in understanding the roles of PHLDA3 in cancer progression. They promote innovative research that can lead to potential biomarker identification and novel treatment strategies.

Our company, with its robust background in molecular biology and a commitment to providing high-quality biological tools, ensures that researchers have access to cutting-edge products like the PHLDA3 Gene Knockout Cell Lines. This expertise underpins our mission to advance scientific discovery and support the research community in their quest for knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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