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PHF20L1 Knockout Cell Lines

Gene: PHF20L1

Official Full Name: PHD finger protein 20 like 1provided by HGNC

Gene Summary: Enables methylation-dependent protein binding activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23033 PHF20L1 Knockout cell line (HeLa) Human PHF20L1 1:3~1:6 Negative Online Inquiry
KO23034 PHF20L1 Knockout cell line (HCT 116) Human PHF20L1 1:2~1:4 Negative Online Inquiry
KO23035 PHF20L1 Knockout cell line (HEK293) Human PHF20L1 1:3~1:6 Negative Online Inquiry
KO23036 PHF20L1 Knockout cell line (A549) Human PHF20L1 1:3~1:4 Negative Online Inquiry

Background

PHF20L1 Gene Knockout Cell Lines are precisely engineered cellular models created to facilitate the study of the PHF20L1 gene, a critical component implicated in various biological processes, including gene expression regulation and cellular stress responses. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines have been designed to produce a complete knockout of the PHF20L1 gene, enabling researchers to analyze the resultant phenotypic alterations and elucidate the gene's function in both normal and pathological conditions.

The primary function of the PHF20L1 Gene Knockout Cell Lines is to serve as a robust system for investigating the gene's roles in cellular mechanisms such as transcriptional regulation, chromatin remodeling, and response to DNA damage. With the knockout of PHF20L1, researchers can study the downstream effects on cellular proliferation, differentiation, and apoptosis, providing invaluable insights into diseases such as cancer, where dysregulation of similar pathways often occurs.

In terms of scientific importance, these cell lines are indispensable tools in both research and clinical settings, offering a platform to explore the implications of PHF20L1 in various genetic disorders and its potential as a therapeutic target. The ability to analyze the effects of gene knockout in a controlled environment allows for a more nuanced understanding of gene function, potentially leading to novel treatment strategies and advancing the field of precision medicine.

What sets the PHF20L1 Gene Knockout Cell Lines apart from traditional knockdown models is the permanence and reliability of the knockout. While RNA interference may provide transient suppression, the stable knockout ensures consistent and reproducible results across experiments. Additionally, the cell lines are adaptable for a wide range of assays, including high-throughput screening and CRISPR/Cas9 functional studies, which enhances their utility in diverse research applications.

In conclusion, the PHF20L1 Gene Knockout Cell Lines represent an essential innovation for researchers and clinicians alike, empowering them to bridge the gap between gene function and disease mechanisms. Our company prides itself on harnessing cutting-edge gene editing technologies and extensive expertise in cell model development, ensuring that our products meet the highest standards of quality and scientific validity.

Please note that all services are for research use only. Not intended for any clinical use.

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