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PHC1 Knockout Cell Lines

Gene: PHC1

Official Full Name: polyhomeotic homolog 1provided by HGNC

Gene Summary: This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38119 PHC1 Knockout cell line (HeLa) Human PHC1 1:3~1:6 Negative Online Inquiry
KO38120 PHC1 Knockout cell line (HCT 116) Human PHC1 1:2~1:4 Negative Online Inquiry
KO38121 PHC1 Knockout cell line (HEK293) Human PHC1 1:3~1:6 Negative Online Inquiry
KO38122 PHC1 Knockout cell line (A549) Human PHC1 1:3~1:4 Negative Online Inquiry

Background

PHC1 Gene Knockout Cell Lines are genetically engineered cellular models designed specifically to study the function of the PHC1 gene, which is integral to the regulation of chromatin structure and gene expression. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a complete loss of function of the PHC1 gene, facilitating the exploration of its role in various biological processes, such as cellular proliferation, differentiation, and response to environmental stimuli.

The key function of these PHC1 knockout cell lines is to enable researchers to dissect the molecular pathways influenced by PHC1. This is achieved through comparative analyses involving wild-type and knockout cell lines, allowing for the identification of changes in gene expression profiles, protein interactions, and cellular phenotypes. The absence of the PHC1 gene serves as a powerful tool for elucidating its contributions to cancer biology, developmental disorders, and potential therapeutic interventions.

From a scientific perspective, these cell lines are crucial for advancing our understanding of chromatin dynamics and epigenetic regulation, which are vital in both research and clinical applications. For instance, they can be instrumental in drug development studies, where pinpointing the role of PHC1 may lead to novel therapeutic targets in oncology.

What sets our PHC1 Gene Knockout Cell Lines apart from alternatives is their validated consistency and reliability in genetic editing, combined with comprehensive characterization data. Unlike other systems that may exhibit off-target effects or incomplete knockouts, our cell lines have undergone rigorous quality control to ensure specificity and efficiency, providing researchers with confidence in their findings.

These knockout cell lines are invaluable tools for researchers and clinicians alike, offering the capability to model disease states and test new hypotheses in a controlled environment. By incorporating these cutting-edge models into their studies, scientists can accelerate discoveries that could lead to groundbreaking advances in biology and medicine.

At our company, we pride ourselves on our expertise in genetic engineering and commitment to providing high-quality biological products. Our thorough research and development process ensures that our offerings not only meet but exceed the expectations of our customers in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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