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PFKP Knockout Cell Lines

Gene: PFKP

Official Full Name: phosphofructokinase, plateletprovided by HGNC

Gene Summary: This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08253 PFKP Knockout cell line (HeLa) Human PFKP 1:3~1:6 Negative Online Inquiry
KO08254 PFKP Knockout cell line (HCT 116) Human PFKP 1:2~1:4 Negative Online Inquiry
KO08255 PFKP Knockout cell line (HEK293) Human PFKP 1:3~1:6 Negative Online Inquiry
KO08256 PFKP Knockout cell line (A549) Human PFKP 1:3~1:4 Negative Online Inquiry

Background

PFKP Gene Knockout Cell Lines represent a cutting-edge tool for molecular biology research, specifically designed to investigate the functional role of the phosphofructokinase, platelet (PFKP) gene in various cellular processes. These cell lines are engineered using CRISPR-Cas9 gene-editing technology, resulting in a precise disruption of the PFKP gene, which encodes a key enzyme in the glycolytic pathway. By modulating the activity of the PFKP protein, these knockout cell lines enable researchers to elucidate its role in metabolic regulation, cellular signaling, and energy homeostasis.

The mechanisms underlying the function of PFKP primarily relate to its influence on glucose metabolism and its potential interactions with other regulatory pathways. In the context of cancer research or metabolic disorders, understanding how PFKP knockout impacts cellular behaviors can illuminate novel therapeutic targets or elucidate disease pathogenesis. Moreover, these cell lines facilitate high-throughput screening and experimental reproducibility, making them invaluable for drug discovery efforts and biomarker identification.

One of the distinct advantages of using PFKP Gene Knockout Cell Lines lies in their specificity and accuracy over traditional methods such as RNA interference or chemical inhibitors, which may exhibit off-target effects. This specificity ensures greater reliability in data interpretation, thereby enhancing the validity of research findings. Additionally, maintaining a standardized cellular background allows for consistent experimental conditions, further streamlining the research process.

For researchers and clinicians, the PFKP Gene Knockout Cell Lines provide a robust platform for innovative studies into the metabolic landscapes of various diseases, paving the way for breakthroughs in personalized medicine and targeted therapies. Our company, with extensive experience in genetic engineering and cellular biology, continually strives to deliver high-quality biological products that empower the scientific community. We are committed to advancing research capabilities through innovative solutions that fuel discovery and drive progress in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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