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PEX26 Knockout Cell Lines

Gene: PEX26

Official Full Name: peroxisomal biogenesis factor 26provided by HGNC

Gene Summary: This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15225 PEX26 Knockout cell line (HeLa) Human PEX26 1:3~1:6 Negative Online Inquiry
KO15226 PEX26 Knockout cell line (HCT 116) Human PEX26 1:2~1:4 Negative Online Inquiry
KO15227 PEX26 Knockout cell line (HEK293) Human PEX26 1:3~1:6 Negative Online Inquiry
KO15228 PEX26 Knockout cell line (A549) Human PEX26 1:3~1:4 Negative Online Inquiry

Background

PEX26 Gene Knockout Cell Lines are specialized cellular models developed to study the functional consequences of the PEX26 gene's absence in mammalian cells. PEX26 is a critical gene associated with peroxisome biogenesis and metabolic regulation, and its knockout provides a valuable tool for elucidating the mechanisms by which peroxisomes influence cellular physiology and disease processes.

These cell lines operate on the principle of targeted gene disruption, utilizing CRISPR/Cas9 technology to induce precise mutations in the PEX26 gene. By disrupting its normal function, researchers can investigate the resultant phenotypic changes, including alterations in peroxisomal function, lipid metabolism, and reactive oxygen species management. This allows for a comprehensive understanding of how PEX26 dysfunction contributes to various metabolic disorders, including Zellweger syndrome and other peroxisomal biogenesis disorders.

The scientific importance of PEX26 Gene Knockout Cell Lines extends into both basic and applied research settings. They serve as pivotal tools for biochemists and molecular biologists in studying metabolic pathways and their implications for human health. Furthermore, they facilitate the testing of potential therapeutic interventions targeting peroxisomal dysfunction, thereby rapidly advancing translational research.

What sets our PEX26 Gene Knockout Cell Lines apart is their high specificity and reproducibility, ensuring rigorous experimental standards. Unlike traditional methods, which often yield off-target effects, our advanced editing techniques guarantee consistent knockout efficiency. Researchers can trust our cell lines to produce reliable data that can inform future studies and potential clinical applications.

Moreover, by providing these unique models, we empower researchers and clinicians alike to accelerate their exploration of gene function and therapeutic strategies. Our commitment to high-quality, innovative biological products reflects our expertise in the field, underscoring our dedication to advancing scientific research and enhancing the understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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