Gene: PELI2
Official Full Name: pellino E3 ubiquitin protein ligase family member 2provided by HGNC
Gene Summary: Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15233 | PELI2 Knockout cell line (HeLa) | Human | PELI2 | 1:3~1:6 | Negative | Online Inquiry |
KO15234 | PELI2 Knockout cell line (HEK293) | Human | PELI2 | 1:3~1:6 | Negative | Online Inquiry |
KO15235 | PELI2 Knockout cell line (A549) | Human | PELI2 | 1:3~1:4 | Negative | Online Inquiry |
PELI2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the PELI2 gene's functional role in various biological processes. PELI2, or Pellino E3 Ubiquitin Protein Ligase 2, is implicated in crucial immunological responses, including signal transduction pathways that regulate inflammation and immunity. The knockout of this gene allows researchers to observe phenotypic changes, assess protein interactions, and evaluate downstream effects within cellular contexts that mimic in vivo conditions.
The primary function of these knockout cell lines lies in their ability to provide a controlled environment for investigating the mechanisms by which PELI2 influences immune responses and other cellular activities. By disrupting the PELI2 gene, researchers can dissect its roles more effectively, elucidating pathways involved in diseases such as cancer and autoimmune disorders. Additionally, these cell lines can be used to screen for novel therapeutic agents that target PELI2-related pathways, establishing them as valuable tools in both basic research and drug discovery.
Scientifically, the importance of PELI2 Gene Knockout Cell Lines is underscored by their applications in translational research, particularly in understanding how modulation of PELI2 activity can impact treatment strategies for immune-related diseases. Compared to alternative genomic manipulation techniques, these knockout cell lines offer a stable, reproducible model that is easier to manipulate and analyze, greatly enhancing the reliability of experimental results.
The unique selling points of our PELI2 Gene Knockout Cell Lines include a high-level efficiency in gene disruption verified through quantitative PCR and Western blot analyses, alongside optimal growth characteristics that ensure their compatibility with various experimental conditions. These advantages make them a superior choice for laboratories focused on cutting-edge immunology research, fostering advancements in our understanding of disease mechanisms.
In summary, the PELI2 Gene Knockout Cell Lines are vital tools that empower researchers and clinicians to explore the complex interactions within immune systems, making them indispensable for breakthroughs in preclinical research and therapeutic development. Our company, with its robust background in producing high-quality biological products, is committed to providing innovative solutions that support the scientific community in their quest for knowledge and therapeutic innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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