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PELI1 Knockout Cell Lines

Gene: PELI1

Official Full Name: pellino E3 ubiquitin protein ligase 1provided by HGNC

Gene Summary: Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including negative regulation of TORC1 signaling; negative regulation of necroptotic process; and protein polyubiquitination. Is active in site of double-strand break. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15236 PELI1 Knockout cell line (HeLa) Human PELI1 1:3~1:6 Negative Online Inquiry
KO15237 PELI1 Knockout cell line (HCT 116) Human PELI1 1:2~1:4 Negative Online Inquiry
KO15238 PELI1 Knockout cell line (HEK293) Human PELI1 1:3~1:6 Negative Online Inquiry
KO15239 PELI1 Knockout cell line (A549) Human PELI1 1:3~1:4 Negative Online Inquiry

Background

PELI1 Gene Knockout Cell Lines are specially engineered cellular models in which the Peli1 gene has been systematically inactivated or “knocked out.” This advanced genetic manipulation allows researchers to study the intricate role of the Peli1 protein in various biological processes, including immune response pathways and regulation of inflammation. The Peli1 protein is known to function as an E3 ubiquitin ligase, playing a pivotal role in the post-translational modification of target proteins, which is essential for diverse cellular activities including signal transduction and apoptosis.

The key function of these knockout cell lines lies in their ability to elucidate the specific contributions of Peli1 to cellular mechanisms involved in immune regulation and disease pathology. By comparing these modified cells to their wild-type counterparts, researchers can gain valuable insights into the impact of Peli1 on signaling cascades that influence both innate and adaptive immunity. This has significant implications in the study of autoimmune diseases, cancers, and therapeutic interventions aimed at modulating immune responses.

PELI1 Gene Knockout Cell Lines present distinct advantages over traditional methods such as RNA interference or chemical inhibitors, providing a stable genetic alteration that allows for long-term studies and more consistent results. Unlike transient knockdown approaches, these knockout models facilitate the examination of Peli1's functional effects under various experimental conditions, enhancing the reproducibility and reliability of research findings.

As a product designed for researchers, clinicians, and academic institutions, these cell lines are invaluable tools for advancing scientific understanding of immune regulation. Their utility in research applications ranges from mechanistic studies to drug discovery, allowing for the development of targeted therapies that can better treat immune-related disorders.

Our company possesses extensive expertise in the development of innovative biological products that meet the evolving needs of the scientific community. With a commitment to quality and customer support, we ensure our products not only empower research but also contribute to significant advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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