Gene: PEG10
Official Full Name: paternally expressed 10provided by HGNC
Gene Summary: This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09559 | PEG10 Knockout cell line (HeLa) | Human | PEG10 | 1:3~1:6 | Negative | Online Inquiry |
KO09560 | PEG10 Knockout cell line (HCT 116) | Human | PEG10 | 1:2~1:4 | Negative | Online Inquiry |
KO09561 | PEG10 Knockout cell line (HEK293) | Human | PEG10 | 1:3~1:6 | Negative | Online Inquiry |
KO09562 | PEG10 Knockout cell line (A549) | Human | PEG10 | 1:3~1:4 | Negative | Online Inquiry |
PEG10 Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the PEG10 (paternally expressed gene 10) gene, which plays a significant role in cellular processes including growth regulation and apoptosis. The knockout of this gene permits researchers to study its functional implications in various biological contexts, particularly in cancer and developmental biology. The unique mechanism of PEG10 involves its association with cellular signaling pathways that can influence tumor progression and differentiation; thus, the knockout lines provide invaluable tools for elucidating the gene's roles in these processes.
In scientific research, these PEG10 Gene Knockout Cell Lines are indispensable for investigating the underlying mechanisms of diseases associated with aberrant PEG10 expression, particularly its involvement in cellular transformation. Their applications range from understanding tumor microenvironments to developing targeted therapies. The ability to knockout PEG10 facilitates experiments to assess the impacts of its absence on cellular behaviors such as proliferation, migration, and response to therapeutic agents, thus informing potential clinical implications.
Compared to other gene-editing methodologies, such as CRISPR or RNA interference, PEG10 knockout cell lines provide a stable and reliable system for long-term studies, eliminating transient effects that can complicate results. Moreover, these cell lines offer researchers a platform to develop consistent experimental designs tailored to explore the intricacies of PEG10-related pathways.
For those working in both academic and clinical settings, our PEG10 Gene Knockout Cell Lines represent a critical advancement in the study of gene function and disease mechanisms. By utilizing these products, researchers can streamline their investigations and enhance the quality of their findings, translating into impactful contributions to scientific knowledge and therapeutic innovation. At [Your Company Name], we are committed to delivering high-quality biological tools supported by rigorous scientific expertise and a commitment to advancing research in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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