Home / PDZK1 Knockout Cell Lines

PDZK1 Knockout Cell Lines

Gene: PDZK1

Official Full Name: PDZ domain containing 1provided by HGNC

Gene Summary: This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09442 PDZK1 Knockout cell line (HeLa) Human PDZK1 1:3~1:6 Negative Online Inquiry
KO09443 PDZK1 Knockout cell line (HEK293) Human PDZK1 1:3~1:6 Negative Online Inquiry
KO09444 PDZK1 Knockout cell line (A549) Human PDZK1 1:3~1:4 Negative Online Inquiry

Background

PDZK1 Gene Knockout Cell Lines are specifically engineered cellular models utilized in advanced biological research to study the function and role of the PDZK1 gene. By employing CRISPR-Cas9 technology, these cell lines have undergone precise genetic modification to effectively disrupt the PDZK1 gene, a critical component implicated in various cellular processes such as signal transduction, cell adhesion, and regulation of ion transporters. The knockout of this gene allows researchers to analyze the resultant phenotypic changes and understand its pathophysiological relevance in diseases such as renal disorders and cancers.

The key mechanism driving the utility of PDZK1 Gene Knockout Cell Lines lies in their ability to provide insights into both the normal and aberrant cellular functions mediated by PDZK1 interactions with other proteins. This allows for a comprehensive evaluation of cellular pathways and offers a robust platform for drug discovery and therapeutic interventions targeting specific molecular pathways. Furthermore, the modeling of PDZK1's absence can elucidate compensatory mechanisms and the impact on various signaling cascades, thereby enhancing our overall understanding of the gene's contributions to cellular homeostasis.

In research and clinical settings, these cell lines serve as vital tools for evaluating potential pharmacological agents, as well as for deciphering the molecular underpinnings of disease. The use of PDZK1 Gene Knockout Cell Lines can significantly reduce the time and cost associated with experimental procedures compared to less specific methodologies such as pharmacological inhibition or RNA interference.

What sets PDZK1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability, providing researchers with precise control over gene expression while maintaining the cellular environment. This unique selling point ensures that results are reproducible and applicable across diverse experimental conditions.

Researchers and clinicians searching for detailed insights into PDZK1's role in cellular processes will find these cell lines invaluable for their high-quality performance and ability to facilitate groundbreaking discoveries. Our company boasts a strong foundation in genetic engineering and cellular biology, ensuring that our products meet the highest standards of scientific rigor and innovation, empowering researchers to drive their studies forward with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.