Gene: PDPR
Official Full Name: pyruvate dehydrogenase phosphatase regulatory subunitprovided by HGNC
Gene Summary: Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15259 | PDPR Knockout cell line (HeLa) | Human | PDPR | 1:3~1:6 | Negative | Online Inquiry |
KO15260 | PDPR Knockout cell line (HCT 116) | Human | PDPR | 1:2~1:4 | Negative | Online Inquiry |
KO15261 | PDPR Knockout cell line (HEK293) | Human | PDPR | 1:3~1:6 | Negative | Online Inquiry |
KO15262 | PDPR Knockout cell line (A549) | Human | PDPR | 1:3~1:4 | Negative | Online Inquiry |
PDPR Gene Knockout Cell Lines are specifically engineered cell models designed to facilitate the study of the phosphodiesterase 4 (PDPR) gene, which plays a pivotal role in various cellular processes, including signal transduction and metabolism. Utilizing state-of-the-art CRISPR/Cas9 technology, these cell lines have been genetically modified to knockout PDPR expression, enabling researchers to investigate the consequences of PDPR deficiency on cell behavior and function.
The primary function of these knockout cell lines is to provide insights into the PDPR gene's regulatory mechanisms and its involvement in biological pathways relevant to cell growth, differentiation, and apoptosis. By eliminating PDPR expression, researchers can examine the resulting phenotypic changes and explore compensatory mechanisms that may arise. This unique approach allows for a deeper understanding of the gene's contribution to physiological and pathological states, making these cell lines indispensable for studying diseases like cancer, metabolic disorders, and neurodegeneration.
The scientific importance of PDPR Gene Knockout Cell Lines extends into both basic research and clinical applications. In research settings, they serve as valuable tools for drug discovery, functional genomics, and biomarker identification. Clinically, they can assist in elucidating mechanisms underpinning disease progression and therapeutic resistance, which is vital for developing targeted treatments.
A distinct advantage of our PDPR Gene Knockout Cell Lines is their superior specificity and reproducibility compared to alternative knockout models, such as those generated by RNA interference. The CRISPR/Cas9 method ensures precise gene deletion and enables the generation of stable cell lines with consistent expression profiles, thus leading to more reliable experimental outcomes.
Researchers and clinicians benefit immensely from these knockout cell lines as they provide a robust platform for exploring biological questions and developing new therapeutic strategies. This product is not just a tool; it's an innovation that supports the advancement of biomedical research by enabling detailed genetic investigations.
Our company is committed to excellence in biotechnology and genetic research. We leverage our expertise in cell line development and molecular biology to provide high-quality products that empower the scientific community. With PDPR Gene Knockout Cell Lines, we are dedicated to supporting impactful discoveries that shape the future of health and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.