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PDIA6 Knockout Cell Lines

Gene: PDIA6

Official Full Name: protein disulfide isomerase family A member 6provided by HGNC

Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32257 PDIA6 Knockout cell line (HeLa) Human PDIA6 1:3~1:6 Negative Online Inquiry
KO32258 PDIA6 Knockout cell line (HCT 116) Human PDIA6 1:2~1:4 Negative Online Inquiry
KO32259 PDIA6 Knockout cell line (HEK293) Human PDIA6 1:3~1:6 Negative Online Inquiry
KO32260 PDIA6 Knockout cell line (A549) Human PDIA6 1:3~1:4 Negative Online Inquiry

Background

PDIA6 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the expression of the PDIA6 gene, a member of the protein disulfide isomerase family involved in the formation of disulfide bonds in newly synthesized proteins. The knockout of PDIA6 not only provides insights into the cellular folding processes but also enables the study of various diseases, including cancer and neurological disorders, where protein misfolding is a key factor.

The primary function of these cell lines is to facilitate the exploration of the physiological and biochemical roles of PDIA6. By silencing this gene, researchers can observe the downstream effects on protein stability, folding efficiency, and subsequent cellular responses. This gene knockout approach allows scientists to dissect pathways that might lead to therapeutic targets, providing an invaluable tool for understanding disease mechanisms at a molecular level.

In both research and clinical settings, the PDIA6 Gene Knockout Cell Lines hold considerable scientific importance. They serve as critical models to investigate the role of PDIA6 in drug response, cellular stress responses, and other cellular mechanisms. Their use can lead to the identification of novel biomarkers and therapeutic strategies in conditions like Alzheimer’s disease, diabetes, and certain cancers.

Unlike traditional cell lines, PDIA6 gene knockout models offer a unique advantage by providing a more accurate representation of the biological implications associated with PDIA6 deficiency. This offers researchers a powerful tool for conducting pathway analyses and validating potential drug targets with a clearer mechanistic understanding.

For researchers, clinicians, and biopharmaceutical companies, the PDIA6 Gene Knockout Cell Lines are invaluable resources that speed up the process of scientific discovery while enhancing reproducibility and reliability in experimental results. Our company, known for its state-of-the-art genetic engineering technologies and commitment to advancing biological research, offers these knockout cell lines as part of a comprehensive suite of biological products designed to empower innovation in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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