Gene: PDE6G
Official Full Name: phosphodiesterase 6Gprovided by HGNC
Gene Summary: This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36167 | PDE6G Knockout cell line (A549) | Human | PDE6G | 1:3~1:4 | Negative | Online Inquiry |
PDE6G Gene Knockout Cell Lines are genetically modified cell lines wherein the phosphodiesterase 6G (PDE6G) gene has been effectively disrupted. This product offers researchers a valuable tool for investigating the role of PDE6G in various biological processes and in the pathology of diseases, particularly those related to visual signal transduction pathways. By utilizing these cell lines, scientists can study the functional consequences of PDE6G ablation, including alterations in cyclic nucleotide signaling.
The key function of PDE6G involves the regulation of intracellular levels of cyclic guanosine monophosphate (cGMP), a crucial second messenger in phototransduction within retinal photoreceptor cells. The knockout of PDE6G allows for a comprehensive examination of the signaling cascades that rely on cGMP, providing insights into retinal degenerative diseases and potentially leading to novel therapeutic strategies targeting these pathways.
In research and clinical settings, the significance of PDE6G Gene Knockout Cell Lines cannot be overstated. They serve as essential platforms for the study of gene function, drug screening, and therapeutic development. Their application extends to areas such as vision research, pharmacology, and molecular genetics, elucidating the mechanisms underlying various disorders and facilitating the identification of biomarkers for disease progression.
One of the standout advantages of our PDE6G Gene Knockout Cell Lines is their specificity and reproducibility. Unlike alternative models that may exhibit variable results, our rigorously validated cell lines ensure consistent experimental outcomes. This precision enhances data reliability and accelerates the pace of research, making them an indispensable resource for scientists aiming to explore PDE6G-related pathways.
For researchers and clinicians looking to deepen their understanding of PDE6G's role in health and disease, these knockout cell lines represent a pivotal innovation. Our company, renowned for its expertise in developing high-quality biological products, is committed to supporting the scientific community with robust tools and resources that drive discovery and advancement in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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