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PDE3A Knockout Cell Lines

Gene: PDE3A

Official Full Name: phosphodiesterase 3Aprovided by HGNC

Gene Summary: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07539 PDE3A Knockout cell line (HeLa) Human PDE3A 1:3~1:6 Negative Online Inquiry
KO07540 PDE3A Knockout cell line (A549) Human PDE3A 1:3~1:4 Negative Online Inquiry

Background

PDE3A Gene Knockout Cell Lines are specifically engineered cell lines in which the phosphodiesterase 3A (PDE3A) gene has been intentionally disrupted or knocked out. This powerful tool allows researchers to study the role of PDE3A, an enzyme involved in the regulation of cyclic nucleotides, particularly cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). By precisely removing PDE3A, researchers can investigate the consequent alterations in cell signaling pathways, metabolic processes, and cellular responses to pharmacological agents.

The functionality of these cell lines is rooted in their ability to mimic physiological and pathophysiological states in vitro, making them invaluable for elucidating the effects of PDE3A on various biological processes, including cell proliferation, apoptosis, and inflammation. In clinical research, understanding PDE3A’s role may reveal its involvement in cardiovascular diseases, neurological disorders, and cancer, thereby offering insights into potential therapeutic targets.

Compared to traditional cell lines, our PDE3A Gene Knockout Cell Lines provide researchers with a more refined model that eliminates the variability associated with wild-type cell lines. This increase in specificity allows for higher accuracy in experimental outcomes, enabling more reliable interpretations of data. They are also compatible with high-throughput screening approaches, making them ideal for drug discovery and development.

For researchers and clinicians focused on precision in biological experiments, our PDE3A Gene Knockout Cell Lines deliver a significant advantage by facilitating the study of targeted gene function. With our commitment to producing high-quality biological products and extensive expertise in molecular biology, we ensure that our cell lines meet rigorous standards for reliability and reproducibility, empowering your research endeavors and advancing scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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