Gene: PDCD4
Official Full Name: programmed cell death 4provided by HGNC
Gene Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01696 | PDCD4 Knockout cell line (HeLa) | Human | PDCD4 | 1:3~1:6 | Negative | Online Inquiry |
KO01697 | PDCD4 Knockout cell line (HCT 116) | Human | PDCD4 | 1:2~1:4 | Negative | Online Inquiry |
KO01698 | PDCD4 Knockout cell line (HEK293) | Human | PDCD4 | 1:3~1:6 | Negative | Online Inquiry |
KO01699 | PDCD4 Knockout cell line (A549) | Human | PDCD4 | 1:3~1:4 | Negative | Online Inquiry |
PDCD4 Gene Knockout Cell Lines are specialized cellular models that have undergone gene editing to disrupt the expression of the PDCD4 (Programmed Cell Death 4) gene. This gene serves a pivotal role in various biological processes, including apoptosis, signaling pathways, and cellular proliferation. By knocking out PDCD4, these cell lines provide researchers with a powerful tool to investigate its functional implications in cancer biology, immune response, and other diseases characterized by dysregulated cell death and survival mechanisms.
The key functionality of PDCD4 Gene Knockout Cell Lines lies in their ability to simulate conditions of PDCD4 deficiency, thus enabling detailed studies on how the deletion of this gene affects cellular behavior. Mechanistically, PDCD4 acts as a tumor suppressor, and its absence can lead to enhanced cellular growth and survival, potentially driving cancer progression. These modified cell lines can be utilized to assess the effects of pharmacological agents, understand gene interactions, and elucidate signaling pathways that are influenced by PDCD4.
The scientific importance of PDCD4 Gene Knockout Cell Lines is underscored by their wide-ranging applications in both research and clinical settings. They are invaluable in drug discovery processes, particularly for cancer therapies targeting apoptotic pathways. Additionally, these cell lines contribute to the understanding of molecular mechanisms underlying diseases, aiding in the development of novel therapeutic strategies.
Compared to traditional cell lines, PDCD4 Gene Knockout Cell Lines offer distinct advantages, including the specificity of gene-targeted alterations, which afford greater control and accuracy in experiments. This precision enhances the reproducibility of results, leading to a more profound understanding of PDCD4's role in human health and disease.
For researchers and clinicians eager to explore the nuances of cellular pathways and therapeutic interventions, PDCD4 Gene Knockout Cell Lines represent a critical resource. These models are designed to empower innovative research and clinical applications, thus advancing scientific knowledge and improving patient outcomes.
Our company specializes in high-quality genetic engineering technologies and provides a robust portfolio of biological products, including PDCD4 Gene Knockout Cell Lines, that facilitate cutting-edge research and development in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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