Gene: PCSK7
Official Full Name: proprotein convertase subtilisin/kexin type 7provided by HGNC
Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33514 | PCSK7 Knockout cell line (HeLa) | Human | PCSK7 | 1:3~1:6 | Negative | Online Inquiry |
KO33515 | PCSK7 Knockout cell line (HCT 116) | Human | PCSK7 | 1:2~1:4 | Negative | Online Inquiry |
KO33516 | PCSK7 Knockout cell line (HEK293) | Human | PCSK7 | 1:3~1:6 | Negative | Online Inquiry |
KO33517 | PCSK7 Knockout cell line (A549) | Human | PCSK7 | 1:3~1:4 | Negative | Online Inquiry |
PCSK7 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) gene. This product provides researchers with a powerful tool to study the functional role of PCSK7 in various biological processes, including protein processing, metabolism, and cell signaling pathways. The knockout of this gene enables scientists to analyze the downstream effects on cellular function, offering insights into the mechanistic pathways influenced by PCSK7.
The primary function of PCSK7 involves its role as a proprotein convertase involved in the cleavage and activation of precursor proteins. By inhibiting or knocking out PCSK7, researchers can investigate its contribution to disorders such as cardiovascular diseases, metabolic syndromes, and certain cancers. These cell lines serve as an invaluable resource for elucidating the pathways involved in disease etiology and progression, making them significant in both research and potential therapeutic developments.
One of the key advantages of our PCSK7 Gene Knockout Cell Lines is their enhanced specificity and reproducibility over alternative methods such as transient knockdown or the use of pharmacological inhibitors. The stable genetic alteration ensures persistent effects on cellular behavior, providing reliable data across multiple experimental conditions. Additionally, our cell lines are rigorously validated and characterized, ensuring that they maintain key phenotypic and genotypic features necessary for impactful research.
For researchers and clinicians aiming to explore the intricacies of PCSK7's role in health and disease, these knockout cell lines represent an exceptional resource that can streamline their investigations and lead to novel therapeutic insights. Our company boasts extensive expertise in the development of high-quality genetic tools, ensuring that our products support innovative research directions and foster advancements in biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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