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PCLAF Knockout Cell Lines

Gene: PCLAF

Official Full Name: PCNA clamp associated factorprovided by HGNC

Gene Summary: Enables chromatin binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32794 PCLAF Knockout cell line (HeLa) Human PCLAF 1:3~1:6 Negative Online Inquiry
KO32795 PCLAF Knockout cell line (HCT 116) Human PCLAF 1:2~1:4 Negative Online Inquiry
KO32796 PCLAF Knockout cell line (HEK293) Human PCLAF 1:3~1:6 Negative Online Inquiry
KO32797 PCLAF Knockout cell line (A549) Human PCLAF 1:3~1:4 Negative Online Inquiry

Background

PCLAF Gene Knockout Cell Lines represent a pivotal tool in genetic research, specifically designed to facilitate the study of gene function and regulation. These cell lines are engineered through precise gene-editing techniques to achieve the knockout of the PCLAF (P53-Controlling Protein Associated Factor) gene, which plays a vital role in cellular processes such as DNA damage repair, cell cycle regulation, and apoptosis. By removing the expression of PCLAF, researchers can elucidate its contributions to tumorigenesis, cell proliferation, and other critical molecular pathways.

The functionality of the PCLAF Gene Knockout Cell Lines is grounded in advanced CRISPR-Cas9 technology that ensures specificity and efficiency in gene disruption. This mechanism allows for targeted edits to the genomic sequence of interest, leading to a complete loss of PCLAF expression in the resultant cell lines. In research environments, these knockout models provide invaluable insights into cancer biology and therapeutic responses, significantly enhancing our understanding of how PCLAF modulation affects cellular dynamics.

The scientific importance of these cell lines extends to both basic and applied research, enabling clinicians and scientists to explore novel therapeutic targets and biomarkers in cancer treatment. Furthermore, their utility in drug screening and functional genomics can accelerate discovery pipelines in pharmaceutical development. Compared to conventional methods for gene knockout, such as homologous recombination, PCLAF Gene Knockout Cell Lines offer greater flexibility, speed, and reproducibility, making them an attractive choice for laboratories aiming to streamline their research.

For researchers and clinicians focusing on cancer biology or related fields, the PCLAF Gene Knockout Cell Lines are indispensable. They provide a robust platform for exploring the role of PCLAF in various biological processes, thus opening avenues for developing innovative therapeutic strategies. With our expertise in genetic engineering and commitment to quality, our company stands at the forefront of delivering superior biological products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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