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PCBP4 Knockout Cell Lines

Gene: PCBP4

Official Full Name: poly(rC) binding protein 4provided by HGNC

Gene Summary: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15320 PCBP4 Knockout cell line (HeLa) Human PCBP4 1:3~1:6 Negative Online Inquiry
KO15321 PCBP4 Knockout cell line (HCT 116) Human PCBP4 1:2~1:4 Negative Online Inquiry
KO15322 PCBP4 Knockout cell line (HEK293) Human PCBP4 1:3~1:6 Negative Online Inquiry
KO15323 PCBP4 Knockout cell line (A549) Human PCBP4 1:3~1:4 Negative Online Inquiry

Background

PCBP4 Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the study of the poly(rC)-binding protein 4 (PCBP4) gene, which plays a critical role in various biological processes, including RNA metabolism, cell growth, and differentiation. By disrupting the PCBP4 gene, these knockout cell lines allow researchers to investigate the specific functions of PCBP4 and its contributions to cellular mechanisms in both normal physiological states and in disease contexts such as cancer and neurodegenerative disorders.

The primary function of PCBP4 is its involvement in the regulation of mRNA translation and stability, impacting gene expression and protein synthesis. When the PCBP4 gene is knocked out, researchers can examine the resultant phenotypic changes, dissect downstream signaling pathways, and evaluate alterations in cellular behavior, thus revealing the gene's ecological significance. This mechanistic understanding is particularly valuable in elucidating the roles of PCBP4 in diseases characterized by aberrant RNA binding and processing.

In research settings, these knockout cell lines are invaluable tools for scientists seeking to elucidate gene function, explore gene interaction networks, or test therapeutic interventions. Their application extends seamlessly into clinical research, where the ramifications of PCBP4's role can inform potential therapeutic targets for diseases involving dysregulated gene expression.

What sets PCBP4 Gene Knockout Cell Lines apart from other genetic models is their specific targeting and validation, which ensures reproducibility and reliability in experiments. Moreover, these cell lines enable high-throughput screening and streamlined identification of compounds that may modulate PCBP4-related pathways, potentially advancing therapeutic development.

For researchers, clinicians, and biotechnology innovators, the availability of PCBP4 Gene Knockout Cell Lines represents a significant advancement in molecular biology research, offering unique insights that can accelerate discoveries in cellular function and disease mechanisms. Our company boasts a strong expertise in genetic engineering and cell line development, committed to providing high-quality biological products that empower scientific inquiry and drive innovation in health and disease research.

Please note that all services are for research use only. Not intended for any clinical use.

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