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PCBD2 Knockout Cell Lines

Gene: PCBD2

Official Full Name: pterin-4 alpha-carbinolamine dehydratase 2provided by HGNC

Gene Summary: Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Involved in positive regulation of DNA-templated transcription. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25187 PCBD2 Knockout cell line (HeLa) Human PCBD2 1:3~1:6 Negative Online Inquiry
KO25188 PCBD2 Knockout cell line (HCT 116) Human PCBD2 1:2~1:4 Negative Online Inquiry
KO25189 PCBD2 Knockout cell line (HEK293) Human PCBD2 1:3~1:6 Negative Online Inquiry
KO25190 PCBD2 Knockout cell line (A549) Human PCBD2 1:3~1:4 Negative Online Inquiry

Background

PCBD2 Gene Knockout Cell Lines are specialized cellular models developed to investigate the biological functions of the PCBD2 gene, which encodes a protein involved in vital metabolic pathways, including folate and neurotransmitter biosynthesis. These knockout cell lines are invaluable tools for researchers aiming to elucidate the role of PCBD2 in various physiological and pathological processes.

The key function of the PCBD2 Gene Knockout Cell Lines revolves around their ability to provide a controlled environment where the PCBD2 gene's absence allows for the study of resultant phenotypic changes. Through loss-of-function assays, scientists can explore how the absence of PCBD2 influences cellular activities such as proliferation, differentiation, and responses to stressors. Moreover, these cell lines facilitate the dissection of metabolic pathways impacted by PCBD2 and its contributions to diseases like neurodevelopmental disorders and certain cancers.

The scientific importance of these knockout cell lines lies in their application in both research and clinical settings, where they can serve as platforms for drug screening, biomarker discovery, and the investigation of gene therapy candidates. By mimicking the genetic alterations observed in various diseases, these cell lines enable researchers to validate therapeutic targets and assess potential interventions.

In comparison to other genetic models, such as overexpression systems, the PCBD2 Gene Knockout Cell Lines provide a unique advantage through their precision in disrupting specific gene function while preserving the overall genetic context of the host cells. This offers a clearer understanding of the gene's role without the confounding effects that may arise from overexpression.

Researchers and clinicians will find exceptional value in these cell lines, as they not only enhance comprehension of PCBD2's biological implications but also pave the way for innovative therapeutic solutions. By integrating advanced genetic engineering techniques and rigorous quality control, our company ensures that these PCBD2 Gene Knockout Cell Lines meet the highest standards needed for impactful biological research. Our commitment to fostering scientific advancement positions us as a trusted partner in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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