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PAX6 Knockout Cell Lines

Gene: PAX6

Official Full Name: paired box 6provided by HGNC

Gene Summary: This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36197 PAX6 Knockout cell line (HeLa) Human PAX6 1:3~1:6 Negative Online Inquiry
KO36198 PAX6 Knockout cell line (HCT 116) Human PAX6 1:2~1:4 Negative Online Inquiry
KO36199 PAX6 Knockout cell line (HEK293) Human PAX6 1:3~1:6 Negative Online Inquiry
KO36200 PAX6 Knockout cell line (A549) Human PAX6 1:3~1:4 Negative Online Inquiry

Background

PAX6 Gene Knockout Cell Lines are engineered cell lines specifically designed to study the PAX6 gene's role in developmental biology and its implications in various diseases. PAX6, a transcription factor crucial for eye and brain development, is often associated with specific congenital disorders, including aniridia and various neurodevelopmental disorders. These knockout cell lines allow researchers to investigate the gene's function by providing a model in which PAX6 is selectively deactivated, enabling the study of resultant phenotypic changes and underlying molecular pathways.

The key function of these cell lines lies in their ability to facilitate loss-of-function studies. By examining the biological consequences of PAX6 knockout, researchers can elucidate the gene’s regulatory network and its contribution to cellular processes such as differentiation, proliferation, and apoptosis. You can also assess the gene's interactions with other signaling pathways, enhancing our understanding of complex genetic and epigenetic interactions.

The scientific importance of PAX6 Gene Knockout Cell Lines extends into both basic research and clinical applications. In research settings, these models are invaluable for studying ocular and neurological development, offering insights into the etiology of disorders linked to PAX6 mutations. Clinically, they hold potential for therapeutic innovations, as understanding PAX6 function can aid in developing targeted treatments for related congenital conditions.

Comparatively, PAX6 Gene Knockout Cell Lines offer several advantages over traditional models, such as mouse models or primary cell cultures. Their ease of use, reproducibility, and the ability to quickly generate results enable researchers to conduct high-throughput screenings and gather data in a more efficient manner. Additionally, these cell lines can provide a more adaptable platform for gene editing technologies, allowing for precise modifications in cellular function.

For researchers and clinicians, the value of PAX6 Gene Knockout Cell Lines lies in their capacity to propel investigations that could lead to breakthroughs in understanding and treating genetic disorders. The utility of these models in diverse research scenarios underscores their relevance and appeal.

At [Your Company Name], we specialize in providing high-quality biological products that support cutting-edge research. Our commitment to excellence and a deep understanding of genetic models ensures that our PAX6 Gene Knockout Cell Lines are reliable tools for advancing scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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