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PARD3 Knockout Cell Lines

Gene: PARD3

Official Full Name: par-3 family cell polarity regulatorprovided by HGNC

Gene Summary: This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08669 PARD3 Knockout cell line (HeLa) Human PARD3 1:3~1:6 Negative Online Inquiry
KO08670 PARD3 Knockout cell line (HCT 116) Human PARD3 1:2~1:4 Negative Online Inquiry
KO08671 PARD3 Knockout cell line (HEK293) Human PARD3 1:3~1:6 Negative Online Inquiry
KO08672 PARD3 Knockout cell line (A549) Human PARD3 1:3~1:4 Negative Online Inquiry

Background

PARD3 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the PARD3 gene, which encodes for the partitioning defective 3 (PARD3) protein, integral to epithelial cell polarity and cellular signaling pathways. These knockout models serve as vital tools for researchers examining the functional roles of the PARD3 protein in various biological processes, including cell division, migration, and tumorigenesis.

The primary mechanism at play involves the disruption of pathways that regulate cell adhesion and polarity. The loss of PARD3 allows scientists to investigate downstream effects on cellular architecture and signaling cascades that are often implicated in cancer metastasis and other diseases. By studying cell behavior in the absence of this critical protein, researchers can gain insights into the molecular underpinnings of diseases and identify potential therapeutic targets.

The scientific importance of PARD3 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In cancer research, these models are invaluable for understanding how disruptions in cellular polarity contribute to malignancy and resistance to therapies. Additionally, in regenerative medicine, they can elucidate mechanisms of cellular differentiation and tissue repair.

Compared to alternative cell lines that retain the PARD3 gene or employ less precise gene editing techniques, our PARD3 Gene Knockout Cell Lines offer unparalleled specificity and reliability. The precision of our gene knockout ensures reproducible results, making these models crucial for experiments requiring high fidelity in understanding gene function.

Researchers and clinicians will find great value in these knockout cell lines, as they accelerate the discovery process and enhance experimental accuracy. By utilizing PARD3 Gene Knockout Cell Lines, users can explore innovative approaches to addressing complex biological questions, ultimately leading to advancements in therapeutic strategies.

Our company brings extensive expertise in the development of genetically modified models, ensuring that researchers have access to high-quality, validated products that significantly contribute to their scientific endeavors. The commitment to excellence in our offerings reflects our dedication to pushing the boundaries of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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