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PAPOLA Knockout Cell Lines

Gene: PAPOLA

Official Full Name: poly(A) polymerase alphaprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31417 PAPOLA Knockout cell line (HeLa) Human PAPOLA 1:3~1:6 Negative Online Inquiry
KO31418 PAPOLA Knockout cell line (HCT 116) Human PAPOLA 1:2~1:4 Negative Online Inquiry
KO31419 PAPOLA Knockout cell line (HEK293) Human PAPOLA 1:3~1:6 Negative Online Inquiry
KO31420 PAPOLA Knockout cell line (A549) Human PAPOLA 1:3~1:4 Negative Online Inquiry

Background

PAPOLA Gene Knockout Cell Lines are advanced biological tools engineered to facilitate the study of gene function and disease mechanisms by enabling precise gene disruption in specific cellular contexts. Utilizing the latest in CRISPR-Cas9 technology, these cell lines allow researchers to effectively create loss-of-function mutations, providing a robust platform for investigating the role of individual genes in cellular behavior, signaling pathways, and various biological processes.

The key mechanism by which PAPOLA Gene Knockout Cell Lines operate involves the targeted introduction of double-strand breaks at predetermined genomic sites. This leads to a subsequent non-homologous end joining (NHEJ) repair process that frequently results in insertions or deletions, ultimately resulting in gene inactivation. This precision ensures that researchers can explore the phenotypic consequences of gene knockout, contributing to a far-reaching understanding of genes implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.

The scientific importance of these cell lines cannot be overstated; they serve as invaluable tools not only for basic research but also for drug discovery and therapeutic development. By providing a clear and reproducible model for studying gene function and interaction, they enable breakthroughs in personalized medicine and targeted therapies. Moreover, PAPOLA Gene Knockout Cell Lines have applications in fields such as molecular biology, genetics, and pharmacology, empowering scientists to unravel complex biological questions.

One significant advantage of PAPOLA Gene Knockout Cell Lines over similar products on the market is their thorough validation and optimization for a range of tissue types and genetic backgrounds. Unlike traditional knockout methodologies, which may produce variable results, PAPOLA ensures consistency and reliability, thereby reducing experimental variability and enhancing reproducibility. Additionally, our commitment to customer support and technical guidance sets us apart, enabling researchers to maximize the potential of these innovative cell lines in their work.

For researchers and clinicians who require robust and accurate gene manipulation tools, PAPOLA Gene Knockout Cell Lines represent a crucial asset in advancing their scientific pursuits. Leveraging the expertise of our team, who are dedicated to delivering high-quality biological products and exceptional support, ensures that you have the resources needed to drive your research forward with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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