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PAK6 Knockout Cell Lines

Gene: PAK6

Official Full Name: p21 (RAC1) activated kinase 6provided by HGNC

Gene Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01415 PAK6 Knockout cell line(293T) Human PAK6 1:3~1:6 Negative Online Inquiry
KO08948 PAK6 Knockout cell line (HeLa) Human PAK6 1:3~1:6 Negative Online Inquiry
KO08949 PAK6 Knockout cell line (HCT 116) Human PAK6 1:2~1:4 Negative Online Inquiry

Background

PAK6 Gene Knockout Cell Lines are genetically engineered cell lines that feature the targeted disruption of the PAK6 gene, which encodes for p21-activated kinase 6, a serine/threonine protein kinase involved in various cellular processes, including cytoskeletal dynamics and cell signaling pathways. These knockout cell lines serve as powerful tools for researchers aiming to investigate the functional consequences of PAK6 loss and its role in physiological and pathological conditions.

The primary mechanism of action of PAK6 involves its participation in the regulation of Rho GTPase signaling, which is critical for cell movement and morphology. By creating a cell line with the PAK6 gene knocked out, scientists can observe alterations in these processes, elucidating the biological pathways it influences and identifying potential targets for therapeutic intervention. The ability to systematically investigate PAK6’s role in diseases, such as cancer and neurodegenerative disorders, highlights its relevance in both basic research and translational medicine.

In research and clinical applications, PAK6 Gene Knockout Cell Lines offer significant advantages over traditional gene manipulation methodologies. By using these ready-to-use knockout lines, researchers can save time and resources typically spent on creating knockout models from scratch. This streamlined approach enhances experimental consistency, allowing for reproducible results across multiple studies. Moreover, the specificity of the gene knockout reduces off-target effects commonly associated with other gene-editing techniques.

For researchers and clinicians, the value of PAK6 Knockout Cell Lines lies in their potential to bridge the gap between fundamental research and therapeutic development. These cell lines not only facilitate in-depth studies of PAK6's function but also provide a platform for testing new drugs aimed at modulating its activity. The insights gained can inform clinical strategies for conditions where PAK6 plays a pivotal role.

Our company, an industry leader in genetic engineering and biological products, is committed to advancing research through innovative solutions. Our expertise ensures that every cell line we offer, including the PAK6 Gene Knockout Cell Lines, is meticulously developed to meet the highest standards of quality and reliability, empowering scientists to make groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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