Gene: PACS1
Official Full Name: phosphofurin acidic cluster sorting protein 1provided by HGNC
Gene Summary: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15387 | PACS1 Knockout cell line (HeLa) | Human | PACS1 | 1:3~1:6 | Negative | Online Inquiry |
KO15388 | PACS1 Knockout cell line (HCT 116) | Human | PACS1 | 1:2~1:4 | Negative | Online Inquiry |
KO15389 | PACS1 Knockout cell line (HEK293) | Human | PACS1 | 1:3~1:6 | Negative | Online Inquiry |
KO15390 | PACS1 Knockout cell line (A549) | Human | PACS1 | 1:3~1:4 | Negative | Online Inquiry |
PACS1 Gene Knockout Cell Lines are specialized cellular models created through the targeted deletion of the PACS1 gene, which has been implicated in various biological processes including vesicle transport, protein sorting, and cellular signaling. This knockout technique utilizes cutting-edge CRISPR-Cas9 technology to induce precise alterations in the genome, enabling researchers to discern the functional role of PACS1 in cellular mechanisms and pathophysiological conditions.
The primary function of PACS1 Knockout Cell Lines lies in their ability to elucidate the consequences of PACS1 gene disruption. By observing changes in cellular behavior, signaling pathways, and overall physiology, researchers can uncover insights into conditions such as neurodevelopmental disorders and cancer. As PACS1 is crucial for endosomal transport and the regulation of receptor signaling, characterizing these knockout cell lines aids in understanding the complexities of cellular communication and its potential disruptions.
In a clinical and research context, these cell lines serve as invaluable tools for exploring therapeutic targets, studying gene function, and developing novel interventions. Utilizing PACS1 Gene Knockout Cell Lines provides researchers with a robust platform for drug discovery and biomarker identification, potentially leading to significant advancements in patient care and treatment strategies.
What sets PACS1 Gene Knockout Cell Lines apart from other cellular models is their precision and reliability. Unlike other models that may still express varying levels of the target gene, our knockout lines ensure a complete ablation of PACS1 expression, offering clarity and accuracy in experimental results. Additionally, they come with comprehensive documentation and support from our expertise, ensuring that scientists can seamlessly incorporate them into their research workflows.
Our company specializes in high-quality genetic models and tools, underpinned by years of expertise in molecular biology and genetics. By choosing PACS1 Gene Knockout Cell Lines, researchers are not just accessing a product; they are partnering with a leader in innovation for advanced biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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