Gene: P2RY1
Official Full Name: purinergic receptor P2Y1provided by HGNC
Gene Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08828 | P2RY1 Knockout cell line (HCT 116) | Human | P2RY1 | 1:2~1:4 | Negative | Online Inquiry |
KO08829 | P2RY1 Knockout cell line (HEK293) | Human | P2RY1 | 1:3~1:6 | Negative | Online Inquiry |
P2RY1 Gene Knockout Cell Lines are advanced genetic models specifically engineered to lack the P2RY1 gene, which encodes for the P2Y1 receptor—a pivotal player in various physiological processes, including platelet aggregation and neuronal signaling. These cell lines enable researchers to study the specific roles of the P2Y1 receptor in cellular functions and contribute to a better understanding of related pathology, including cardiovascular diseases and neurodegenerative disorders.
The key function of these knockout cell lines lies in their capability to elucidate the physiological and pathological roles of the P2Y1 receptor. By comparing the knockout variants with their wild-type counterparts, scientists can investigate receptor-mediated signaling pathways and their downstream effects on cellular functions, such as Ca2+ mobilization and gene expression regulation. This functional differentiation is critical for uncovering potential therapeutic targets or biomarkers in disease modeling.
In both research and clinical settings, P2RY1 Gene Knockout Cell Lines are instrumental in drug discovery and development, particularly in evaluating potential therapeutic agents aimed at modulating P2Y1 receptor activity. Their significance extends to studying receptor desensitization, trafficking, and the biomolecular mechanisms underlying various disorders, making these models a valuable asset for translational research.
One of the distinct advantages of our P2RY1 Gene Knockout Cell Lines is their precise genetic modification, which ensures consistent results and reproducibility across experiments. Unlike other alternatives, such as transient knockdown methods, these stably modified cell lines provide a reliable platform for long-term studies, facilitating extended experimental designs without the variability often seen in transient systems.
We recognize the critical need for advanced biological tools in the life sciences. Our expertise in generating high-quality gene knockout models ensures that researchers and clinicians can leverage our products to drive innovation and discovery in their fields. By choosing our P2RY1 Gene Knockout Cell Lines, users access not only a product but also a commitment to scientific excellence and support tailored to their specific research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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