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OSR1 Knockout Cell Lines

Gene: OSR1

Official Full Name: odd-skipped related transcription factor 1provided by HGNC

Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transporter activity; positive regulation of gastrulation; and pronephros development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26630 OSR1 Knockout cell line (HCT 116) Human OSR1 1:2~1:4 Negative Online Inquiry
KO26631 OSR1 Knockout cell line (A549) Human OSR1 1:3~1:4 Negative Online Inquiry

Background

OSR1 Gene Knockout Cell Lines are specifically engineered cellular models designed to lack the OSR1 gene, a crucial regulator in various signaling pathways that affect cellular growth and differentiation. These cell lines serve as a powerful tool for researchers investigating the role of OSR1 in physiological and pathological processes, particularly in the context of kidney development, electrolyte homeostasis, and hypertension.

The primary function of OSR1 Gene Knockout Cell Lines lies in their ability to facilitate the study of gene function by eliminating OSR1 expression, thereby allowing for the observation of phenotypic changes and cellular responses. By employing techniques such as CRISPR-Cas9 gene editing, these cell lines provide a means to dissect the downstream signaling pathways influenced by OSR1, enabling a deeper understanding of its role in the regulation of sodium transport and renal function.

The scientific importance of these cell lines is underscored by their applications in both basic research and clinical settings. They are invaluable in studies focused on the mechanisms of renal diseases, cardiovascular health, and the molecular underpinnings of genetic disorders associated with electrolyte imbalance. Moreover, findings derived from these models contribute significantly to the development of therapeutic strategies, including targeted gene therapies and pharmacological interventions.

Compared to alternative models, OSR1 Gene Knockout Cell Lines offer the unique advantage of being specifically tailored to eliminate OSR1 function with high specificity and minimal off-target effects. This specificity ensures that researchers can derive accurate and reliable data, reducing the risk of confounding results often associated with less discriminative techniques.

For researchers and clinicians, the value of OSR1 Gene Knockout Cell Lines lies in their ability to unlock complex biological questions and to provide insights that are critical for both fundamental discoveries and translational applications. By utilizing these advanced models, users can accelerate their research outcomes and foster innovations in the field of gene therapy.

Our company specializes in the development of high-quality biological products that empower scientific research. With robust expertise in cellular biology and genetic engineering, we are committed to providing tools that enable groundbreaking discoveries in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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