Gene: OR51B2
Official Full Name: olfactory receptor family 51 subfamily B member 2provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15451 | OR51B2 Knockout cell line (HCT 116) | Human | OR51B2 | 1:2~1:4 | Negative | Online Inquiry |
OR51B2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the OR51B2 gene, which encodes for an olfactory receptor involved in physiological processes including sensory transduction and neurobiology. These knockout cell lines have been genetically engineered to disrupt the OR51B2 gene, allowing researchers to investigate the gene's role in cellular signaling pathways and its implications in various biological contexts, including taste, smell, and potential therapeutic targets for olfactory-related disorders.
The key functions of the OR51B2 Gene Knockout Cell Lines arise from their ability to provide a controlled environment for examining the effects of the absence of the OR51B2 gene. Researchers can utilize these models to elucidate signaling cascades initiated by other receptors, evaluate compensatory mechanisms within olfactory pathways, and perform high-throughput screening assays for novel compounds that may interact with olfactory receptors. The precise knockout of the OR51B2 gene ensures that developmental and physiological studies remain faithful to in vivo conditions, thereby enhancing the translational relevance of the findings.
The scientific importance of these cell lines is unparalleled—due to their applications in both fundamental research and clinical settings. They offer a unique platform for the investigation of olfactory receptor signaling pathways, enabling insights into the molecular mechanisms underlying sensory perception and the development of olfactory-related compounds. This data is critical not only for basic neuroscience research but also for potential applications in the development of drugs aimed at addressing neurological disorders or enhancing sensory functions.
Compared to alternative cellular models, such as wild-type or non-specific knockout lines, OR51B2 Gene Knockout Cell Lines provide a more targeted and reliable method for gene function analysis. They eliminate variability associated with background expression of the OR51B2 gene, thereby delivering clearer and more interpretable results. This specificity affords researchers enhanced reproducibility and reliability, two factors paramount in rigorous scientific investigation.
For researchers, clinicians, and pharmaceutical developers, the use of OR51B2 Gene Knockout Cell Lines is invaluable. They not only expand the understanding of olfactory signaling but also pose a significant opportunity for innovation in the field, as the findings derived from such models could lead to breakthroughs in therapeutic avenues targeting olfactory-related disorders. Our company prides itself on its commitment to providing high-quality biological products, backed by robust scientific validation and expertise, to support the advancement of research and clinical applications in the life sciences sector.
Please note that all services are for research use only. Not intended for any clinical use.
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