Gene: OR4A8
Official Full Name: olfactory receptor family 4 subfamily A member 8 (gene/pseudogene)provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25815 | OR4A8 Knockout cell line (HeLa) | Human | OR4A8 | 1:3~1:6 | Negative | Online Inquiry |
KO25816 | OR4A8 Knockout cell line (HCT 116) | Human | OR4A8 | 1:2~1:4 | Negative | Online Inquiry |
KO25817 | OR4A8 Knockout cell line (HEK293) | Human | OR4A8 | 1:3~1:6 | Negative | Online Inquiry |
KO25818 | OR4A8 Knockout cell line (A549) | Human | OR4A8 | 1:3~1:4 | Negative | Online Inquiry |
OR4A8 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the expression of the OR4A8 gene, which encodes for a member of the olfactory receptor family. These knockout lines serve as critical tools for studying the functional roles of olfactory receptors in various biological processes, including sensory perception, signal transduction, and cellular communication. By eliminating the OR4A8 gene, researchers can investigate the effects on cellular behavior, metabolic pathways, and overall physiological responses, thereby enhancing our understanding of how olfactory signals contribute to organismal biology.
The primary function of these knockout cell lines is to provide a controlled environment for evaluating gene function and protein interactions, enabling researchers to dissect the complex signaling mechanisms initiated by olfactory receptors. The lack of this specific receptor can unravel compensatory pathways or alternative signaling cascades that come into play in its absence, providing invaluable insights into receptor biology and its implications for health and disease.
In scientific research, OR4A8 Gene Knockout Cell Lines are pivotal not only for fundamental studies but also for applications in drug discovery, where they can be utilized to screen for compounds that modulate olfactory receptor activity. Their clinical significance extends to understanding diseases related to olfaction and taste, as well as potential therapeutic avenues for conditions impacted by olfactory signaling.
Compared to conventional cell lines, the OR4A8 knockout models offer unique advantages, including a defined genetic background, specificity in receptor function studies, and reproducibility in experimental outcomes. These features enable enhanced experimental rigor, making them a superior choice for researchers focused on olfactory pathways.
For researchers and clinicians looking to elucidate the complexities of sensory biology, the OR4A8 Gene Knockout Cell Lines provide an unparalleled resource to advance their work. Our company specializes in delivering high-quality, rigorously validated biological products and services, ensuring that researchers have the tools they need for innovation and discovery in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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