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ODAD2 Knockout Cell Lines

Gene: ODAD2

Official Full Name: outer dynein arm docking complex subunit 2provided by HGNC

Gene Summary: The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15533 ODAD2 Knockout cell line (HeLa) Human ODAD2 1:3~1:6 Negative Online Inquiry
KO15534 ODAD2 Knockout cell line (HCT 116) Human ODAD2 1:2~1:4 Negative Online Inquiry
KO15535 ODAD2 Knockout cell line (HEK293) Human ODAD2 1:3~1:6 Negative Online Inquiry

Background

ODAD2 Gene Knockout Cell Lines represent a groundbreaking advancement in genetic research and therapeutic development. These cell lines are engineered to have a targeted deletion of the ODAD2 gene, allowing scientists to study the gene's specific functions and regulatory networks without interference from the genetic influences typically present in wild-type cells. The process of gene knockout is achieved through CRISPR-Cas9 technology, which provides a precise and efficient means of editing the genome.

The primary function of ODAD2 gene knockout cell lines is to facilitate the exploration of the gene’s role in cellular processes such as immune response, cellular differentiation, and proliferation. By eliminating the ODAD2 gene, researchers can investigate downstream effects on signaling pathways, gene expression profiles, and cellular behaviors, offering valuable insights into the molecular mechanisms underlying various diseases, including autoimmune disorders and certain cancers.

Scientifically, these cell lines are of immense importance, as they serve as powerful tools for both in vitro and in vivo studies. They can be utilized in drug discovery, efficacy screening, and functional genomics, providing a robust platform for researchers looking to understand genetic contributions to health and disease. Furthermore, their applications extend into clinical settings where they may help in identifying new therapeutic targets or elucidating the pathology behind specific conditions.

The unique selling points of ODAD2 Gene Knockout Cell Lines lie in their specificity and reliability. Unlike traditional methods, which often yield non-specific results, our knockout lines offer consistency and reproducibility, which are critical for robust scientific research. Additionally, these cell lines are provided with comprehensive protocols and support, ensuring ease of use and facilitating integration into existing research workflows.

For researchers and clinicians alike, the value of our ODAD2 Gene Knockout Cell Lines is evident in their capacity to accelerate discovery and innovation. By providing a clear understanding of gene function, these cell lines will benefit studies aimed at developing new therapeutic strategies and improving patient care.

Our company prides itself on its commitment to advancing biological research through high-quality products and services. With expertise in genetic engineering and a dedication to supporting the scientific community, we are excited to offer ODAD2 Gene Knockout Cell Lines as a part of our extensive portfolio of innovative biological tools.

Please note that all services are for research use only. Not intended for any clinical use.

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