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OASL Knockout Cell Lines

Gene: OASL

Official Full Name: 2'-5'-oligoadenylate synthetase likeprovided by HGNC

Gene Summary: Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33974 OASL Knockout cell line (HeLa) Human OASL 1:3~1:6 Negative Online Inquiry
KO33975 OASL Knockout cell line (HCT 116) Human OASL 1:2~1:4 Negative Online Inquiry
KO33976 OASL Knockout cell line (A549) Human OASL 1:3~1:4 Negative Online Inquiry

Background

OASL Gene Knockout Cell Lines represent a powerful tool in molecular biology, specifically designed for investigations into gene function and regulation. These cell lines have been genetically engineered to have the OASL (2'-5'-oligoadenylate synthetase-like) gene disrupted, allowing researchers to study the specific roles and pathways associated with OASL in cellular responses to viral infections and stress.

The knockout mechanism utilized in these cell lines employs advanced CRISPR-Cas9 technology, which ensures precise gene editing and enables researchers to create models that lack OASL expression. This mechanism allows for detailed examination of how the absence of OASL influences cellular signaling pathways, immune responses, and anti-viral defenses. The exquisite control over the OASL gene offers insights into its function in innate immunity, potentially leading to novel therapeutic strategies against viral diseases and elucidating the gene's roles in other biological processes.

The scientific significance of OASL Gene Knockout Cell Lines extends to various applications in both basic and applied research. In clinical settings, these cell lines can aid in the development of targeted therapies and vaccines by providing a reliable platform for screening compounds that modulate immune responses. Additionally, they advance our comprehension of pathogen-host interactions, particularly concerning OASL's involvement in RNA virus infections.

Compared to alternative methods like RNA interference, OASL Gene Knockout Cell Lines offer a permanent genetic alteration that facilitates long-term studies and repetitive experimental designs, ensuring consistent results across experiments. This stability in the gene knockout enables researchers to conduct longitudinal studies without the variations often associated with transient knockdown techniques.

Researchers and clinicians seeking to deepen their understanding of viral pathogenesis and immunity will find OASL Gene Knockout Cell Lines invaluable. Our company prides itself on its commitment to providing high-quality, cutting-edge biological products, backed by years of expertise in genetic engineering and molecular biology. With these specialized cell lines, you gain access to a robust resource that enhances your research capabilities and accelerates discoveries in the field of immunology and virology.

Please note that all services are for research use only. Not intended for any clinical use.

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