Gene: Npnt
Official Full Name: nephronectinprovided by MGI
Gene Summary: Enables integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of metabolic process. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regulation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in basement membrane; extracellular region; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bilateral renal aplasia. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01233 | Npnt Knockout cell line (MC3T3-E1 Subclone 14) | Mouse | Npnt | 1:3~1:5 | Negative | Online Inquiry |
Npnt Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the expression of the Npnt gene, a critical factor in cellular interactions with the basal membrane, particularly in the context of tissue development and maintenance. These knockout cell lines are invaluable tools for researchers investigating the biological roles of Npnt in various physiological processes, such as cell adhesion, migration, and differentiation. By manipulating the Npnt gene, scientists can observe the resultant cellular behaviors and elucidate the gene's functions through in vitro experiments.
The primary mechanism that these knockout cell lines utilize lies in the disruption of Npnt-mediated signaling pathways, which can affect a plethora of cellular functions including extracellular matrix interactions and cell-to-cell communication. This disruption creates a platform for studying the resultant phenotypic changes, facilitating insights into diseases linked to aberrant Npnt expression, such as cancer and developmental disorders.
In the research and clinical arenas, Npnt Gene Knockout Cell Lines serve a dual role: they provide a reliable model for drug discovery and therapeutic interventions while enabling the study of disease mechanisms at a molecular level. These cell lines offer researchers the ability to replicate specific genetic contexts, yielding more accurate data relevant to human biology compared to traditional models.
What sets our Npnt Gene Knockout Cell Lines apart from other products on the market is their validated background and robust cellular performance, ensuring reproducible results across experiments. Each line undergoes extensive characterization, confirming the absence of Npnt expression and providing reassurance to researchers about the integrity and reliability of their models.
Investing in Npnt Gene Knockout Cell Lines equips researchers, clinicians, and pharmaceutical companies with the tools they need to advance their studies and accelerate discoveries in genetics and cellular biology. Our company prides itself on its expertise in generating high-quality biological products, underpinned by cutting-edge technology and an unwavering commitment to scientific excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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