Gene: NXT1
Official Full Name: nuclear transport factor 2 like export factor 1provided by HGNC
Gene Summary: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27129 | NXT1 Knockout cell line (HeLa) | Human | NXT1 | 1:3~1:6 | Negative | Online Inquiry |
KO27130 | NXT1 Knockout cell line (HCT 116) | Human | NXT1 | 1:2~1:4 | Negative | Online Inquiry |
KO27131 | NXT1 Knockout cell line (HEK293) | Human | NXT1 | 1:3~1:6 | Negative | Online Inquiry |
KO27132 | NXT1 Knockout cell line (A549) | Human | NXT1 | 1:3~1:4 | Negative | Online Inquiry |
NXT1 Gene Knockout Cell Lines are specialized human or murine cell lines that have undergone targeted gene disruption of the NXT1 gene, which encodes for the Nucleotide Excision Repair (NER) pathway protein involved in RNA export and cellular homeostasis. By utilizing advanced CRISPR-Cas9 genome editing technology, these cell lines enable researchers to study the precise effects of NXT1 gene loss on cellular function and gene expression, providing critical insights into various biological processes and disease mechanisms.
The key functionality of NXT1 Gene Knockout Cell Lines lies in their ability to facilitate a more in-depth understanding of gene function and its broader implications in oncogenesis, infectious diseases, and neurobiology. Through the knockout of NXT1, researchers can explore the impact on RNA metabolism, cell cycle regulation, and stress responses, which can significantly inform therapeutic strategies and elucidate underlying pathophysiological conditions.
Scientifically, these cell lines are invaluable tools in both research and clinical settings. Their applications extend across diverse fields, such as cancer research, where they can be utilized to identify novel therapeutic targets, and virology, in studying host-pathogen interactions. The specificity of the NXT1 knockout enables more precise experimental conditions, reducing background noise associated with off-target effects common in less refined models.
NXT1 Gene Knockout Cell Lines offer unique advantages when compared to traditional knockout models, including enhanced efficiency in gene targeting, supporting reproducibility in experimental results, and reducing laboratory time and costs. Unlike earlier methods that may provide partial or imprecise gene deletion, the CRISPR-assisted approach guarantees a complete loss of function, offering unmatched reliability.
For researchers and clinicians, the ability to manipulate the NXT1 gene and thereby control cellular pathways opens vast potential for discovering new insights that could drive future innovations in diagnostics and therapeutics. Our commitment to delivering high-quality, well-characterized biological products ensures that each NXT1 Gene Knockout Cell Line meets rigorous scientific standards, empowering you to expand the horizons of your research and clinical applications. Trust in our expertise to provide you with essential tools that advance your discoveries in the biomedical field.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.