Gene: NUCKS1
Official Full Name: nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC
Gene Summary: This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15594 | NUCKS1 Knockout cell line (HeLa) | Human | NUCKS1 | 1:3~1:6 | Negative | Online Inquiry |
KO15595 | NUCKS1 Knockout cell line (HCT 116) | Human | NUCKS1 | 1:2~1:4 | Negative | Online Inquiry |
KO15596 | NUCKS1 Knockout cell line (HEK293) | Human | NUCKS1 | 1:3~1:6 | Negative | Online Inquiry |
KO15597 | NUCKS1 Knockout cell line (A549) | Human | NUCKS1 | 1:3~1:4 | Negative | Online Inquiry |
NUCKS1 Gene Knockout Cell Lines are specially engineered cell models that facilitate the functional study of the NUCKS1 gene, which plays a crucial role in cellular processes, including DNA repair, proliferation, and apoptosis. By utilizing CRISPR-Cas9 technology, these cell lines enable researchers to knock out the NUCKS1 gene effectively, thereby allowing for the investigation of its biological functions and interactions within cellular mechanisms.
The key function of NUCKS1 Gene Knockout Cell Lines lies in their ability to provide insights into the phenotypic alterations that occur when the NUCKS1 gene is removed. This process offers a robust platform for understanding the implications of NUCKS1 on cell cycle regulation, response to genotoxic stress, and the molecular pathways involved in tumorigenesis. Employing these knockout cell lines can significantly enhance experimental outcomes in research focusing on cancer, neurodegenerative diseases, and other conditions where NUCKS1 may play a pivotal role.
Scientifically, these cell lines are invaluable in both research and clinical settings. They provide researchers with an essential tool for validating therapeutic targets, testing drug responses, and elucidating disease mechanisms. The ability to manipulate gene expression through knockout strategies is fundamental for developing personalized medicine approaches and understanding the genetic underpinnings of diseases.
Compared to alternative models, such as siRNA-mediated knockdown or conventional wild-type cell lines, NUCKS1 Gene Knockout Cell Lines offer unparalleled specificity and permanence. This makes them less prone to off-target effects and allows for long-term studies on the implications of NUCKS1 loss. Furthermore, they are compatible with various assays, including high-throughput screening and in vivo studies, enhancing their applicability across different experimental setups.
For researchers and clinicians seeking a reliable and efficient means to uncover the role of NUCKS1 in various biological contexts, these knockout cell lines represent a significant advancement. Our company, with its extensive expertise in cell line engineering and genetic modifications, is committed to providing high-quality biological products that propel scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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