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NUAK2 Knockout Cell Lines

Gene: NUAK2

Official Full Name: NUAK family kinase 2provided by HGNC

Gene Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Located in nuclear speck. Implicated in anencephaly. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03281 NUAK2 Knockout cell line (HeLa) Human NUAK2 1:3~1:6 Negative Online Inquiry
KO03282 NUAK2 Knockout cell line (HCT 116) Human NUAK2 1:2~1:4 Negative Online Inquiry
KO03283 NUAK2 Knockout cell line (A549) Human NUAK2 1:3~1:4 Negative Online Inquiry

Background

NUAK2 Gene Knockout Cell Lines are specifically engineered cell lines in which the NUAK2 gene has been selectively disrupted. This genetic modification enables researchers to investigate the biological implications of NUAK2 absence, a protein kinase implicated in various cellular processes, including energy metabolism and mitosis. By creating knockout models, scientists can study the role of NUAK2 in alternative pathways and its involvement in numerous disease states, particularly cancer and metabolic disorders.

The primary function of these knockout cell lines is to facilitate the elucidation of NUAK2's role in cellular signaling and its potential as a therapeutic target. Without the expression of the NUAK2 kinase, researchers can observe resultant phenotypic changes, altered growth patterns, and differences in metabolic regulation, providing invaluable insights into the kinase's functions. The mechanism by which these knockout lines operate is rooted in CRISPR/Cas9 genome editing technology, ensuring precise and efficient gene disruption.

In research and clinical contexts, NUAK2 Gene Knockout Cell Lines serve as essential tools for understanding NUAK2-related signaling pathways, validating drug targets, and exploring the cellular mechanisms underlying diseases. Their relevance extends beyond basic research, as they can substantially impact drug discovery and development, leading to the identification of novel therapeutic strategies.

What sets our NUAK2 Gene Knockout Cell Lines apart from other cellular models is their unparalleled specificity and reproducibility, coupled with our commitment to high-quality standards in genetic engineering. The precise targeting of NUAK2 ensures that the resultant data is robust and translatable to real-world applications.

For researchers and clinicians keen on advancing their understanding of metabolic regulation and cancer biology, these knockout cell lines represent a vital resource. Our company specializes in providing top-tier biological products backed by extensive scientific expertise and rigorous quality assurance processes, ensuring that our customers receive tools that will empower their research and clinical endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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