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NTS Knockout Cell Lines

Gene: NTS

Official Full Name: neurotensinprovided by HGNC

Gene Summary: This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05754 NTS Knockout cell line (HeLa) Human NTS 1:3~1:6 Negative Online Inquiry
KO05755 NTS Knockout cell line (HEK293) Human NTS 1:3~1:6 Negative Online Inquiry
KO05756 NTS Knockout cell line (A549) Human NTS 1:3~1:4 Negative Online Inquiry

Background

NTS Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to eliminate the expression of the neurotensin receptor gene (NTS). This innovative product allows researchers to study the role of neurotensin signaling in various physiological and pathological processes. By using CRISPR-Cas9 technology or other gene-editing techniques, these cell lines provide a robust platform for investigating the functions of neurotensin, a peptide that plays a critical role in modulating neurogenic inflammation, hormone secretion, and neuroprotection.

The primary function of NTS Gene Knockout Cell Lines lies in their ability to serve as a controlled environment for unraveling the complexities of neurotensin signaling. Researchers can observe how the absence of this receptor influences cellular responses, including proliferation, differentiation, and apoptosis. This valuable insight can lead to breakthroughs in understanding diseases such as cancer, obesity, and neurological disorders, where neurotensin signaling is implicated.

In clinical and research settings, these cell lines are instrumental for drug discovery, functional assays, and the development of therapeutics targeting neurotensin pathways. Their high fidelity and specificity in gene knockout provide a unique advantage over conventional methods that may only partially inhibit receptor function, ensuring that study results are both reliable and reproducible.

Compared to alternative products, NTS Gene Knockout Cell Lines stand out due to their ease of use along with the comprehensive validation provided by our team of scientists. Each cell line is thoroughly characterized, ensuring consistent performance across experiments. This reliability allows researchers to focus on their experimental designs rather than on variable results.

In addition, these cell lines come with detailed protocols and support documentation, making them accessible even to laboratories with limited gene-editing experience. Their value is further enhanced by our commitment to ongoing technical support and updates based on the latest research.

With a proven track record in developing innovative biological tools, our company brings extensive expertise in cellular biology and gene editing. We are dedicated to providing high-quality products that empower scientific discovery, and our NTS Gene Knockout Cell Lines are a testament to this commitment, equipping researchers and clinicians with a pivotal resource to advance their work in neurobiology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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