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NTF4 Knockout Cell Lines

Gene: NTF4

Official Full Name: neurotrophin 4provided by HGNC

Gene Summary: This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10580 NTF4 Knockout cell line (HCT 116) Human NTF4 1:2~1:4 Negative Online Inquiry
KO10581 NTF4 Knockout cell line (A549) Human NTF4 1:3~1:4 Negative Online Inquiry

Background

NTF4 Gene Knockout Cell Lines are specialized cellular models derived through targeted gene editing techniques, specifically designed to investigate the functional implications of the neurotrophin factor 4 (NTF4) gene in cellular processes and disease mechanisms. By utilizing CRISPR-Cas9 technology, these cell lines enable precise deletion or modification of the NTF4 gene, allowing researchers to explore its role in neuronal development, survival, and signaling pathways critical for neurological health.

The primary function of NTF4 is to promote the growth, differentiation, and survival of specific neurons, particularly those in the peripheral nervous system. By creating knockout models, scientists can elucidate the gene's contribution to neuroinflammatory responses, neurodegenerative diseases, and sensory neuron function. These alterations facilitate the detailed study of underlying mechanisms in various pathologies, allowing for a deeper understanding of how NTF4 influences neuronal health and disease progression.

The scientific importance of these knockout cell lines extends across myriad research applications, including developmental biology, neurobiology, and pharmacology. Their ability to mimic diseases provides a platform for drug discovery and testing, enabling the screening of potential therapeutics that can modulate NTF4-related signaling pathways. This opens up possibilities for innovative treatment approaches in conditions such as neuropathies and neurodegenerative disorders.

What sets our NTF4 Gene Knockout Cell Lines apart from conventional cell models is their precise genetic modification and the resulting robust phenotype characterization, which provides enhanced reliability in experimental outcomes. Unlike traditional or non-specific models, these knockout lines deliver consistent and reproducible results that are critical for advancing basic and applied research.

For researchers and clinicians, the availability of NTF4 Gene Knockout Cell Lines is invaluable as they facilitate a deeper inquiry into the molecular underpinnings of neurobiology, lead to breakthrough therapeutic strategies, and significantly enhance the potential for translational research. Our company harnesses a wealth of expertise in developmental biology and gene editing technology, ensuring that our products not only meet but exceed the rigorous demands of modern scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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