Gene: NSUN6
Official Full Name: NOP2/Sun RNA methyltransferase 6provided by HGNC
Gene Summary: Enables tRNA (cytidine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. Implicated in autosomal recessive intellectual developmental disorder 82. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27557 | NSUN6 Knockout cell line (HeLa) | Human | NSUN6 | 1:3~1:6 | Negative | Online Inquiry |
KO27558 | NSUN6 Knockout cell line (HCT 116) | Human | NSUN6 | 1:2~1:4 | Negative | Online Inquiry |
KO27559 | NSUN6 Knockout cell line (HEK293) | Human | NSUN6 | 1:3~1:6 | Negative | Online Inquiry |
KO27560 | NSUN6 Knockout cell line (A549) | Human | NSUN6 | 1:3~1:4 | Negative | Online Inquiry |
NSUN6 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the NSUN6 gene, which encodes a member of the RNA methyltransferase family. These cell lines serve as invaluable tools in molecular biology research, particularly in the areas of gene expression regulation and RNA metabolism. By analyzing the functional consequences of NSUN6 knockout, researchers can gain insights into the gene's role in cellular processes, including ribosome biogenesis, translation, and stress responses.
The primary mechanism of action of NSUN6 involves its function in methylating ribosomal RNA, thereby influencing ribosome assembly and protein synthesis efficiency. By knocking out this gene, researchers can observe changes in ribosomal RNA modifications and, consequently, alterations in protein synthesis dynamics. Moreover, these cell lines can be pivotal for studying diseases linked to dysregulated RNA methylation, such as certain cancers and genetic disorders.
The scientific importance of NSUN6 Gene Knockout Cell Lines lies in their application across various research facets, including the exploration of genomic stability, cellular stress responses, and translational control, making them crucial for both basic and applied biomedical research.
Compared to alternative models, this product offers the advantage of a specific and reproducible alteration in gene function, which allows for a clearer interpretation of experimental results. The knockout aspect circumvents the redundancy often observed in gene families, enabling a more straightforward analysis of phenotypic changes.
For researchers and clinicians alike, the NSUN6 Gene Knockout Cell Lines represent a critical resource for advancing our understanding of molecular mechanisms at play in human health and disease. They provide a robust framework for unraveling complex biological systems, which can foster breakthroughs in therapeutic interventions and targeted treatments.
At our company, we pride ourselves on our extensive expertise in generating precision-engineered biological tools. Our commitment to cutting-edge research and product innovation positions us as a leader in the field, ensuring that our customers have access to the highest quality resources for their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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