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NSMCE2 Knockout Cell Lines

Gene: NSMCE2

Official Full Name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligaseprovided by HGNC

Gene Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15621 NSMCE2 Knockout cell line (HeLa) Human NSMCE2 1:3~1:6 Negative Online Inquiry
KO15622 NSMCE2 Knockout cell line (HCT 116) Human NSMCE2 1:2~1:4 Negative Online Inquiry
KO15623 NSMCE2 Knockout cell line (HEK293) Human NSMCE2 1:3~1:6 Negative Online Inquiry
KO15624 NSMCE2 Knockout cell line (A549) Human NSMCE2 1:3~1:4 Negative Online Inquiry

Background

NSMCE2 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate in-depth investigation of the NSMCE2 gene, which is critically involved in DNA repair mechanisms and cellular stress responses. This product allows researchers to create models that lack the functional NSMCE2 protein, enabling them to assess the gene's biological role and its implications in various pathologies, including cancer and genomic instability.

The NSMCE2 Gene Knockout Cell Lines operate through a precise gene-editing approach, often employing CRISPR-Cas9 technology, which enables targeted disruption of the NSMCE2 gene. This mechanism allows for robust studies into the gene's effect on cell proliferation, apoptosis, and response to DNA damage, all of which are pivotal in understanding tumorigenesis and treatment resistance. Utilizing these knockout cell lines, researchers can systematically dissect pathways influenced by NSMCE2, providing insights that were previously unattainable with wild-type models.

The scientific importance of NSMCE2 Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings. These models serve as pivotal tools for investigating the mechanisms behind DNA repair and chromosome maintenance, offering valuable data that can inform therapeutic strategies for various malignancies. By studying these knockout lines, researchers can also explore the potential of NSMCE2 as a biomarker for cancer prognosis or treatment response.

Compared to alternative cell models, NSMCE2 Gene Knockout Cell Lines present unique advantages, including a straightforward validation of gene function, a well-defined genetic background, and the ability to mimic specific diseases through controlled genetic perturbation. Such cell lines facilitate reproducibility and consistency, key factors in advancing experimental outcomes.

For researchers and clinicians alike, these knockout cell lines represent an invaluable resource for elucidating the intricacies of gene function and its impact on human health. They enable improved understanding of cancer biology and the development of innovative therapeutic modalities.

Our company specializes in providing high-quality, expertly validated biological products tailored for modern research needs. With a commitment to advancing scientific discovery, our NSMCE2 Gene Knockout Cell Lines are a testament to our dedication to excellence and innovation in the field of genomics.

Please note that all services are for research use only. Not intended for any clinical use.

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