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NSMAF Knockout Cell Lines

Gene: NSMAF

Official Full Name: neutral sphingomyelinase activation associated factorprovided by HGNC

Gene Summary: This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07646 NSMAF Knockout cell line (HeLa) Human NSMAF 1:3~1:6 Negative Online Inquiry
KO07647 NSMAF Knockout cell line (HCT 116) Human NSMAF 1:2~1:4 Negative Online Inquiry
KO07648 NSMAF Knockout cell line (HEK293) Human NSMAF 1:3~1:6 Negative Online Inquiry
KO07649 NSMAF Knockout cell line (A549) Human NSMAF 1:3~1:4 Negative Online Inquiry

Background

NSMAF Gene Knockout Cell Lines are specialized mammalian cell lines that have been genetically engineered to lack functional NSMAF (Neuro-Suppressor of MAF) expression. This innovative product is designed to facilitate the investigation of NSMAF's role in cellular mechanisms, disease models, and potential therapeutic targets. By employing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines provide a reliable platform for researchers to study the functional consequences of NSMAF deletion in various biological contexts.

The key function of NSMAF Gene Knockout Cell Lines lies in their ability to elucidate the molecular pathways influenced by NSMAF, a protein implicated in neurological disorders and cancer development. Researchers can utilize these knockout models to assess changes in cell proliferation, differentiation, and response to stressors, thereby helping to unravel the complex interactions within cellular signaling pathways. This functional insight is essential for identifying potential drug targets or biomarkers relevant to human health.

In terms of scientific importance, NSMAF Gene Knockout Cell Lines have far-reaching applications in both basic and translational research. They serve as valuable tools in understanding the etiology of diseases where NSMAF is implicated, such as certain types of neurodegeneration and tumorigenesis. Additionally, these models can be employed in drug discovery efforts, aiding in the assessment of therapeutic compounds designed to modulate NSMAF-related pathways.

What sets NSMAF Gene Knockout Cell Lines apart from alternative products is their precise gene editing approach, which ensures the highest degree of specificity and consistency in genetic modification. This precision reduces the potential for off-target effects, allowing for more reliable experimental outcomes and interpretations. Furthermore, they are readily adaptable to high-throughput screening methods, enhancing their utility in extensive research environments.

For researchers and clinicians seeking to deepen their understanding of NSMAF's contributions to disease mechanisms, our NSMAF Gene Knockout Cell Lines present an invaluable resource. By utilizing these cell lines, users can engage in cutting-edge research with robust implications for the development of innovative therapeutic strategies. At our company, we pride ourselves on providing high-quality, validated biological products backed by a team of experts committed to advancing scientific discovery and patient care.

Please note that all services are for research use only. Not intended for any clinical use.

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