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NRG2 Knockout Cell Lines

Gene: NRG2

Official Full Name: neuregulin 2provided by HGNC

Gene Summary: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33129 NRG2 Knockout cell line (HCT 116) Human NRG2 1:2~1:4 Negative Online Inquiry
KO33130 NRG2 Knockout cell line (HEK293) Human NRG2 1:3~1:6 Negative Online Inquiry
KO33131 NRG2 Knockout cell line (A549) Human NRG2 1:3~1:4 Negative Online Inquiry

Background

NRG2 Gene Knockout Cell Lines are genetically engineered cellular models designed to completely disrupt the expression of the neuregulin-2 (NRG2) gene. These cell lines represent a powerful tool for researchers investigating the role of NRG2 in cellular signaling pathways, neurodevelopment, and various physiological processes. By utilizing techniques such as CRISPR/Cas9 gene editing, these cell lines enable the precise examination of gene function and its implications in both normal and pathological contexts.

The primary mechanism of NRG2 gene knockout involves the creation of targeted mutations that result in the loss of NRG2 expression. This knockout leads to valuable insights into the cellular mechanisms that NRG2 regulates, including its involvement in neuronal development, synaptic plasticity, and potential contributions to neuropsychiatric disorders. Researchers can employ these cell lines to elucidate the pathological roles of NRG2 in diseases like schizophrenia and Alzheimer's, which may ultimately guide the discovery of new therapeutic strategies.

From a scientific perspective, NRG2 Gene Knockout Cell Lines hold significant importance in basic and translational research settings. They allow for in-depth functional assays, drug testing, and biomarker discovery, providing researchers with the ability to explore the intricate biology associated with NRG2’s functionality. Compared to traditional wild-type cell lines, the knockout variants offer a clear advantage by eliminating confounding factors, which improves the reliability and reproducibility of experimental outcomes.

What sets NRG2 Gene Knockout Cell Lines apart from alternative products is their superior specificity and efficiency in knocking out the gene of interest. This specificity ensures high fidelity in experimental designs and yields data that are critical in advancing our understanding of NRG2-related pathways.

For researchers and clinicians dedicated to understanding complex biological processes, NRG2 Gene Knockout Cell Lines represent an invaluable asset. Their application extends from fundamental research to potential clinical advancements, facilitating the exploration of novel insights into cell biology and therapeutic interventions.

At our company, we specialize in the production and development of high-quality, genetically engineered cell lines that empower scientists in their quest for discovery. We remain committed to supporting research initiatives with innovative products that enhance scientific understanding and address pressing clinical needs.

Please note that all services are for research use only. Not intended for any clinical use.

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