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NR6A1 Knockout Cell Lines

Gene: NR6A1

Official Full Name: nuclear receptor subfamily 6 group A member 1provided by HGNC

Gene Summary: This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07238 NR6A1 Knockout cell line (HeLa) Human NR6A1 1:3~1:6 Negative Online Inquiry
KO07239 NR6A1 Knockout cell line (HCT 116) Human NR6A1 1:2~1:4 Negative Online Inquiry
KO07240 NR6A1 Knockout cell line (HEK293) Human NR6A1 1:3~1:6 Negative Online Inquiry
KO07241 NR6A1 Knockout cell line (A549) Human NR6A1 1:3~1:4 Negative Online Inquiry

Background

NR6A1 Gene Knockout Cell Lines are specialized cellular models that lack the expression of the NR6A1 gene, a key transcription factor implicated in various developmental and physiological processes. By utilizing these knockout cell lines, researchers are afforded a powerful tool to dissect the biological roles of NR6A1 in gene regulation, cell differentiation, and disease pathogenesis. The absence of NR6A1 allows for the investigation of its downstream effects on cellular pathways, providing insights into its role in oncogenesis, metabolic regulation, and stem cell function.

The primary mechanism by which these cell lines operate revolves around the gene-editing technology used to create the knockout, typically employing CRISPR/Cas9 or similar genome editing systems. This allows precise removal or inactivation of the NR6A1 gene, facilitating controlled experiments that lead to a comprehensive understanding of its function within various cellular contexts. Researchers can observe changes in gene expression profiles, cellular morphology, and biochemical pathways that are directly influenced by the absence of NR6A1.

The scientific importance of NR6A1 Gene Knockout Cell Lines is evident in multiple research and clinical applications. These models are instrumental in studies related to cancer research, where NR6A1's regulatory roles in tumorigenesis are explored, as well as in regenerative medicine, where understanding its function could improve stem cell therapies.

What sets our NR6A1 Gene Knockout Cell Lines apart from alternatives is the rigor of the genetic validation process and the consistency of the knockout efficiency, ensuring reproducibility in experimental results. Furthermore, these lines are provided with detailed characterization and comprehensive support for optimal experimental design, making them accessible to researchers with varying levels of expertise.

For researchers and clinicians, the ability to precisely modulate gene function using NR6A1 knockout systems represents an invaluable resource in advancing knowledge in molecular biology. By integrating these cell lines into their studies, users can derive meaningful insights that can contribute to novel therapeutic strategies and enhance our understanding of complex biological systems.

Our company specializes in high-quality cell line development and is committed to providing support throughout your research journey, ensuring that you have access to the resources and knowledge necessary to leverage our products effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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