Gene: NR4A2
Official Full Name: nuclear receptor subfamily 4 group A member 2provided by HGNC
Gene Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36288 | NR4A2 Knockout cell line (HeLa) | Human | NR4A2 | 1:3~1:6 | Negative | Online Inquiry |
KO36289 | NR4A2 Knockout cell line (HCT 116) | Human | NR4A2 | 1:2~1:4 | Negative | Online Inquiry |
KO36290 | NR4A2 Knockout cell line (HEK293) | Human | NR4A2 | 1:3~1:6 | Negative | Online Inquiry |
KO36291 | NR4A2 Knockout cell line (A549) | Human | NR4A2 | 1:3~1:4 | Negative | Online Inquiry |
NR4A2 Gene Knockout Cell Lines are genetically engineered cells that lack the NR4A2 gene, which encodes a member of the nuclear receptor family known to be crucial in several physiological processes, including neurodevelopment and the regulation of various metabolic pathways. By employing CRISPR-Cas9 technology, these cell lines serve as a powerful tool for researchers investigating the specific roles of NR4A2 in cellular functions, disease states, and drug responses.
The primary function of NR4A2 is its role as a transcription factor that modulates the expression of genes involved in neuronal differentiation, survival, and inflammation. Knockout of this gene allows for the elucidation of its functions and downstream pathways in key biological processes. Researchers can utilize these cell lines to understand the implications of NR4A2 in conditions such as Parkinson’s disease, obesity, and diabetes, providing insights into potential therapeutic interventions.
The scientific importance of NR4A2 Gene Knockout Cell Lines extends to a variety of applications in both research and clinical settings. Their ability to produce reproducible and robust data makes them invaluable for drug screening, biomarker discovery, and mechanistic studies of disease. Additionally, these cell lines can be employed in high-throughput screening assays, significantly accelerating the discovery process in pharmacology and toxicology.
Unique selling points of NR4A2 Gene Knockout Cell Lines include their customizability for specific research needs, unmatched reliability due to rigorous validation processes, and robust support for experimental design. Unlike other knockouts, the precision of CRISPR-Cas9 technology ensures minimal off-target effects, allowing researchers to confidently associate experimental outcomes with NR4A2 function.
For researchers, clinicians, and biopharmaceutical professionals, utilizing NR4A2 Gene Knockout Cell Lines offers a strategically significant advantage in understanding complex biological systems and advancing translational research. These cell lines not only enhance the scientific community’s capacity to investigate vital physiological processes but also enable the development of innovative therapies affecting critical health issues.
Our company specializes in providing high-quality biological products, backed by years of expertise in genetic engineering and cell biology. With a commitment to supporting scientific advancement, we offer comprehensive resources and technical support to collaborators seeking to leverage the full potential of NR4A2 Gene Knockout Cell Lines in their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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