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NPY4R2 Knockout Cell Lines

Gene: NPY4R2

Official Full Name: neuropeptide Y receptor Y4-2provided by HGNC

Gene Summary: Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20934 NPY4R2 Knockout cell line (HeLa) Human NPY4R2 1:3~1:6 Negative Online Inquiry
KO20935 NPY4R2 Knockout cell line (A549) Human NPY4R2 1:3~1:4 Negative Online Inquiry

Background

NPY4R2 Gene Knockout Cell Lines are innovative biological tools developed for advanced research in neurobiology and endocrine signaling. These cell lines feature targeted deletions of the neuropeptide Y receptor Y4 (NPY4R2), which is critical in regulating appetite, anxiety, and energy homeostasis. Through CRISPR/Cas9 gene editing techniques, these knockout cell lines provide a reliable and reproducible platform for investigating the physiological roles of NPY4R2 in various biological processes.

The primary function of these knockout cell lines lies in their ability to elucidate the molecular pathways mediated by NPY4R2. By disabling this receptor, researchers can uncover how its absence affects neurotransmitter release, neuronal development, and metabolic functions. These insights are particularly valuable in studying disorders such as obesity, depression, and anxiety, where dysregulation of neuropeptide systems is often implicated. This makes NPY4R2 knockout lines crucial assets for both basic research and drug development, enabling targeted investigations into therapeutic strategies.

Compared to conventional cell lines, NPY4R2 knockout models present distinct advantages, such as specificity and minimal off-target effects, ensuring that findings are both reliable and relevant. These cell lines also streamline research workflows, reducing the time and resources needed to generate stable knockout models from scratch. Furthermore, the specificity of NPY4R2 disruption provides clarity in experimental results, allowing for more profound investigations into receptor-targeted therapies.

Researchers and clinicians will find immense value in these cell lines as they pave the way for breakthroughs in understanding neuropeptide function and therapeutic intervention for related disorders. The creation and validation of the NPY4R2 knockout models exemplify the commitment to quality and innovation at our company, positioning us as leaders in biological product development. Our expertise in gene editing technologies underpins our continued dedication to providing researchers with exceptional tools for advancing their studies in molecular biology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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