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NPM3 Knockout Cell Lines

Gene: NPM3

Official Full Name: nucleophosmin/nucleoplasmin 3provided by HGNC

Gene Summary: The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31956 NPM3 Knockout cell line (HeLa) Human NPM3 1:3~1:6 Negative Online Inquiry
KO31957 NPM3 Knockout cell line (HCT 116) Human NPM3 1:2~1:4 Negative Online Inquiry
KO31958 NPM3 Knockout cell line (HEK293) Human NPM3 1:3~1:6 Negative Online Inquiry
KO31959 NPM3 Knockout cell line (A549) Human NPM3 1:3~1:4 Negative Online Inquiry

Background

NPM3 Gene Knockout Cell Lines are advanced cellular tools specifically engineered to facilitate the investigation of nucleophosmin (NPM3), a nuclear protein implicated in cell proliferation and tumorigenesis. By employing CRISPR/Cas9 gene-editing technology, these cell lines are designed to effectively disrupt the NPM3 gene, allowing researchers to evaluate the molecular mechanisms that underlie its functions and associated pathologies.

The core function of these knockout cell lines involves the complete abrogation of NPM3 expression, enabling studies on how its absence influences cellular processes such as growth, differentiation, and stress responses. This is crucial for understanding the roles of NPM3 in various cancers, as its overexpression is linked to oncogenesis. Furthermore, the knockout model provides a unique platform for exploring compensatory mechanisms within the cell's signaling pathways and the impact on treatment responses to chemotherapeutics.

In research and clinical settings, NPM3 Gene Knockout Cell Lines represent a significant advancement in the quest for targeted therapeutics. Their application spans fundamental studies in cancer biology to the testing of novel cancer drugs, positioning these cell lines as essential refrains in oncology research. The cell lines provide reliable reproducibility and ease of use compared to traditional methods of gene silencing, such as RNA interference, which may yield off-target effects.

One unique selling point of NPM3 Gene Knockout Cell Lines is their speed of initiation; researchers can begin experiments shortly after acquisition, minimizing the timeline to gaining insights and translation findings into potential therapies. Additionally, they come with comprehensive technical support, ensuring users can maximize their research potential.

By investing in NPM3 Gene Knockout Cell Lines, researchers and clinicians gain invaluable resources that drive innovative discoveries, ultimately paving the way for breakthroughs in cancer treatment. Our company specializes in offering high-quality, precision biological products informed by rigorous scientific expertise, ensuring that users are equipped with the best tools to advance their research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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